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Quantification of MR Spectra in Human Brain using LCModel

Quantification of MR Spectra in Human Brain using LCModel. Shireen Farvin HM-Meeran Masters in Bio-Medical Engineering Wayne State University Thesis Committee Members: Dr. Jiani Hu Dr. E. Mark Haacke. Research Interest.

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Quantification of MR Spectra in Human Brain using LCModel

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  1. Quantification of MR Spectra in Human Brain using LCModel Shireen Farvin HM-Meeran Masters in Bio-Medical Engineering Wayne State University Thesis Committee Members: Dr. Jiani Hu Dr. E. Mark Haacke

  2. Research Interest Automatic quantification of in vivo proton MR spectra using LCModel. To estimate metabolite concentrations Normal Human brain and Various Tumor cases at 4T field strength.

  3. Methods • The metabolite concentrations were obtained using LCmodel quantification algorithm. • LCmodel analyses the in vivo spectrum as a linear combination of individual in vitro metabolite spectra that constitute a basis set. • The basis set used in this study consisted of spectra from the following metabolites: NAA, choline, creatine, glutamate, glutamine and GABA.

  4. BASIS-SET

  5. BASIS-SET

  6. Test Phantom Results The ultimate goal of this research is to apply this basis-set on Traumatic Brain Injured patients to estimate the metabolite concentrations.

  7. Thank You!!!

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