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George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO University of Thessaly, Larissa, Greece

European Stroke Conference / Stroke Guidelines. A short introduction on. George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO University of Thessaly, Larissa, Greece. Nice 08/05/2014. Disclosures. Scholarships: European Stroke Organization; Hellenic Society of Atherosclerosis.

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George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO University of Thessaly, Larissa, Greece

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  1. European Stroke Conference / Stroke Guidelines A short introduction on George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO University of Thessaly, Larissa, Greece Nice 08/05/2014

  2. Disclosures Scholarships: European Stroke Organization; Hellenic Society of Atherosclerosis. Honoraria: Medtronic; Quintiles. Speaker fees: Sanofi; Boehringer-Ingelheim. Consultant fees: Boehringer-Ingelheim. Support to attend conferences: Bayer; Sanofi-Aventis; Pfizer; Lundbeck; Boehringer-Ingelheim; Galenica;Elpen; Bristol Myers Squibb. Participation in trials: • ENOS / National co-ordinator (Greece). • BPREVISE / Principal investigator. • FOURIER / Sub-investigator. • GLORIA / Sub-investigator.

  3. GRADE Grading of Recommendations, Assessment, Development and Evaluation

  4. Specify the PICO question(s)

  5. Assessment of quality of studies • RCTs start high • Observational studies start low

  6. Assessment of quality of studies (downgrade) • Study design and execution (bias) • Inconsistency (heterogeneity, I2) • Indirectness • Imprecision (number of events, confidence intervals) • Publicationbias (funnel plot)

  7. Assessment of quality of studies (upgrade) • Large magnitude of the effect • Dose – response relation

  8. Grade of evidence

  9. Summary of Findings (SoF) tables

  10. Panel discussion • Overview

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