Dr.Ramesh Pawar Moderator : Dr.D.G.Dambhare

1. Reducing Absenteeism From Gastrointestinal andRespiratory Illness in Elementary School Students: ARandomized, Controlled Trial of an Infection-ControlIntervention • Thomas J. Sandora, Mei-Chiung Shih, Donald A. Goldmann Dr.Ramesh Pawar Moderator : Dr.D.G.Dambhare Volume 121, Number 6, June 2008

2. Introduction • In US 36.4 million children of elementary school age (5–13 years) in 2004. • 31.1 million were enrolled in elementary school. • Children in this age group are at risk of developing respiratory and gastrointestinal infections, most commonly caused by exchange of secretions and inadequate hand hygiene • School-aged children are often absent b/o illnesses. • These absences also result in lost time from work for parents and substantial costs related to physician visits and antibiotic prescriptions.

3. Introduction … • Several approaches to reducing infections are plausible • Hand hygiene is generally accepted as the best means to prevent the transmission of infections • Hand-washing interventions have been shown to reduce absenteeism among elementary school students • Alcohol-based hand sanitizers are an effective alternative to hand-washing

4. Introduction … • Environmental disinfection is another approach to reducing exposure to infections in school settings. • Many available disinfectants contain ingredients that rapidly kill bacteria and viruses. • A preschool-based intervention focused on environmental cleaning and disinfection resulted in a decrease in the total number of illnesses • Combining school disinfection programs with a hand hygiene component may further reduce absenteeism caused by common illnesses.

5. Objectives • To assess the effectiveness of a multi factorial infection-control intervention, including alcohol-based hand sanitizer and surface disinfection, in reducing absenteeism caused by gastrointestinal and respiratory illnesses among elementary school students. • To describe the viral and bacterial contamination of common surfaces in a typical elementary school classroom. • To assess the impact of an environmental disinfectant on the presence of selected viruses and bacteria on these surfaces.

6. Learning objective • To study randomized control study design.

7. Methodology • Study design: cluster-randomized, controlled trial. • Study area:single elementary school system (classrooms located in 2 buildings) located in Avon,Ohio. • Study participants: elementary school children's in Avon school. • Study period: 8 wks ( March to May 2006)

8. Methodology • Eight third-grade classrooms • located in 1 building (split into 4 teams of 2 • classrooms each; each classroom within a team rotates • through a specified set of rooms for that team during • the school day), and 4 fourth-grade classrooms (1 • team of 4 classes) and 3 fifth-grade classrooms (1 team • of 3 classes) located in another building participated in • the study. To be eligible for the study, a student had to • be a member of 1 of these classrooms. A written • recruitment letter that was cosigned by the classroom • teacher was distributed through the school to all of the

9. Methodology Building 1 3rd grade 3rd grade 3rd grade 3rd grade 3rd grade 3rd grade 3rd grade 3rd grade 4 Teams Bulding 2 4th grade 4th grade 4th grade 4th grade 1 Teams 5th grade 5th grade 5th grade 1 Teams

10. Methodology … • A written recruitment letter that was cosigned by the classroom teacher was distributed through the school to all of the families of eligible students. • A student’s parent or guardian either provided written consent to participate or declined participation by means of an opt-out postcard. • If neither the opt-out card nor the consent form was received, the child’s teacher or study personnel called the parent or guardian to remind them to respond. • Students also provided written assent to participate. Teachers provided a separate written consent to participate in the study. • No eligible students who expressed interest in participating were excluded.

11. Methodology • Clustered randomization was used to assign classrooms to intervention or control groups, with the team as the unit of randomization. • This randomization scheme was selected because classes in each team share classroom space within the school, and students on a given team were, therefore, likely to be correlated. • Randomization was also stratified by team size; because 2 teams of 4th & 5th grades > 4 teams 3rd grade. • Author ensured that each group would contain 1 larger team and 2 smaller teams. • The allocation sequence was generated by computer, and teams were assigned to study groups by a study investigator (Dr Shih).

12. Assessed for eligibility (n = 363 students) Excluded (n = 78) Refused to participate (n = 63) No contact made (n = 15) Randomly assigned (n = 285) Allocated to control (n = 139) (3 teams, 8 classrooms) Allocated to intervention (n = 146) (3 teams, 7 classrooms) Lost to follow-up (n = 0) Discontinued intervention (n = 0) Lost to follow-up (n = 0) Discontinued intervention (n = 0) Analyzed (n = 146) Excluded from analysis (n = 0) Analyzed (n = 139) Excluded from analysis (n = 0)

13. Interventions.. • In each intervention classroom, teachers were given a container of disinfecting wipes (Clorox Disinfectin Wipes [The Clorox Company, Oakland, CA]; active ingredient, 0.29% quaternary ammonium chloride compound) to disinfect the students’ desks once daily (after lunch). The individual containers of wipes were labeled by assigned classroom. • All of the disinfecting wipes containers were placed on a shelf in the classroom. Teachers were instructed by the research team on how to use the wipes properly. The individually labeled empty containers were collected once every 3 weeks from the classroom to assess adherence. • In addition, each intervention classroom was provided with prelabeled 1.7-oz containers of alcohol-based hand sanitizer (AeroFirst non aerosol alcohol-based foaming hand sanitizer [DEB SBS Inc, Stanley, NC, for The Clorox Company]; active ingredient, 70% ethyl alcohol). • Students were instructed by study personnel on proper hand-hygiene techniques using the sanitizer.

14. Intervention.. • Students were asked to use the hand sanitizer before and after lunch, after use of the restroom (on return to the classroom; hand hygiene with soap and water occurred in the restroom, because sanitizers were not placed there), and after any contact with potentially infectious secretions (eg, after exposure to other ill children or shared toys that had been mouthed). • Teachers in the intervention classrooms were responsible for encouraging the use of the disinfecting wipes and hand sanitizer and collection of empty product container and distribution of new product.

15. Intervention.. • In control classrooms, the usual baseline cleaning procedures and hand hygiene practices were followed. • Students whose families declined to participate were not asked to use hand sanitizer and were not questioned regarding family characteristics or illnesses (and their absences recorded as part of usual school procedure were excluded from analysis). • Classroom cleaning, disinfection, and microorganism sampling occurred as planned in the designated classrooms.

16. Data collection and Definition • Existing school policy requires that a parent or guardian call to report absences for their children. • All of the student absences were recorded in the usual fashion by the school employee who normally answers this dedicated telephone line. • This employee was blinded to the group assignment of the child. In addition to recording the name of the child and the date of the absence, this individual recorded the reason for the absence on a standardized form. • from which the absence was classified as respiratory or gastrointestinal illness related (or not illness related) according to protocol-specified definitions. • A respiratory illness was defined as an acute illness that included 1 of the following symptoms: runny nose, stuffy or blocked nose, cough, fever or chills, sore throat, or sneezing. • A gastrointestinal illness was defined as an acute illness that included 2 watery or much looser-than-normal bowel movements and stools over a 24-hour period and/or vomiting.

17. Specimen collection • Swabs for bacteria and viruses from 3 types of classroom surfaces (desktops, computer mice, and water fountains) were obtained once per week during the first 5 study weeks. • Four desktops from each classroom were selected at random and sampled each week. • In addition, 1 water fountain and 2 computer mice in each classroom were also sampled once weekly. • All of the samples were collected by the teachers, who received training from study personnel on sample collection. • Surface samples were obtained by swabbing each individual surface with a sterile polyester fiber-tipped transport system collection swab moistened in transport medium (BBL Culture swabs [Becton Dickinson and Company, Sparks, MD]). • All of the samples were delivered overnight to the University of Arizona laboratory on ice and frozen at 80°C until assayed. • The laboratory used for this study was chosen because it has experience processing swabs from environmental surfaces for viral pathogens in previous research studies

18. Results

19. Table 1.Baseline demographic characteristics

20. Baseline demographic characteristics

21. Table 2.Absences for Gastrointestinal and Respiratory Illness

22. TABLE3: Predictors of Absenteeism

23. TABLE 4 Norovirus Detection on Classroom Surfaces

24. TABLE 4 bacterial colony count on classroom surface

25. Results • Compared with the control group, the unadjusted absenteeism rate for gastrointestinal illness was significantly lower in the intervention group (rate ratio: 0.86 [95% confidence interval (CI): 0.79 – 0.94]; P .01). • The unadjusted absenteeism rate for respiratory illness was not different between the groups; the intervention to control group rate ratio was 1.07 (95% CI: 0.92–1.24; P .39).

26. Results • In comparing all of the samples across the entire study period, norovirus was detected on significantly fewer surfaces in intervention classrooms when compared with controls (9% of intervention classroom samples were positive vs 29% of control samples; P .01).

27. Discussion • Multidisciplinary infection-control intervention, consisting of surface disinfection plus alcohol- based hand-sanitizer use, reduced the absenteeism rate for gastrointestinal illness in elementary school classrooms. • The absenteeism rate for respiratory illness was not reduced by this intervention

28. Discussion • A 10% to 15% reduction in absenteeism, the effect size seen in our study, would correspond with a substantial number of additional days in school that are currently being lost to these illnesses • intestinal infectious diseases in the United States may approach 100 million cases annually, and these illnesses cost $23 billion per year in health care expenditures and lost productivity. • Intervention have substantial impact on both public health and resource use

29. Other studies • Kotch et al performed a cluster-randomized trial of a multi component hygienic intervention in child care centres. • The surface disinfection in group setting study of inf. Control program in specialized school for down syndrome suggest less prevalence in intervention grp than pre intervention.

30. Limitations • The Study design is not factorial and hence not able to determine the relative contributions of hand hygiene and surface disinfection to achieving a reduction in absenteeism from gastrointestinal illnesses. • Because illness definitions were symptom based instead of microbiologically confirmed, the possibility for misclassification exists. • As author did not perform diagnostic tests on ill children, cannot definitively state that the observed reduction in absenteeism is linked to the observed reduction in environmental pathogens. • As study took place in a single school system, the results may not be generalizable to other schools where demographics or infrastructure are substantially different.

31. Conclusion • Multifaceted intervention that included alcohol-based hand sanitizer use and disinfection of common classroom surfaces reduced absenteeism from gastrointestinal illness among elementary school students. • No impact of absenteeism from respiratory illness. • Norovirus was detected less frequently on class room surface in intervention group. • Schools should consider incorporating these simple infection-control interventions in the classroom to reduce the number of days lost caused by common illnesses

32. Thank you……