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Molecular Epidemiology Research and Training Program

Molecular Epidemiology Research and Training Program. Major Focus: Environmental Exposures such as Smoking Molecular Genetic Alteration such as DNA Damage Gene-Environmental Interaction on Risk of Cancer. Introduction. Established in 1975, Training 5 pre-doc and 2 post-doc fellows

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Molecular Epidemiology Research and Training Program

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  1. Molecular Epidemiology Research and Training Program Major Focus: Environmental Exposures such as Smoking Molecular Genetic Alteration such as DNA Damage Gene-Environmental Interaction on Risk of Cancer

  2. Introduction • Established in 1975, Training 5 pre-doc and 2 post-doc fellows • NCI Funded Training Program in Molecular Genetic Epidemiology of Cancer • Directed by Dr. Zuo-Feng Zhang, and co-directed by Dr. Roger Detels. • Offered by the Department of Epidemiology, UCLA School of Public Health • Currently accepting applications for pre- (PhD) and post-doctoral positions.

  3. Structure of T32 Training Program

  4. Research Training Opportunities • Methods in Genetic and Molecular Epidemiology • Laboratory Training in Molecular Assays • Molecular Studies of Smoking-related cancers (lung, oral, esophagus, liver, stomach, bladder) • Molecular Studies of HIV-AIDS-related cancers (NHL, KS)

  5. Cancer Molecular Epidemiology Studies • Environmental Exposure and Cancer • Genetic Molecular Markers and Susceptibility of Cancer • Gene-Environmental Interaction on the risk of Cancer

  6. Current Post-Doc Trainees Dr. Amy Lee Dr. Heather Tarleton

  7. Current Pre-Doctoral Trainees Lani Park Sam Oh

  8. Current Pre-Doc Trainees WANG, YI REN PECKHAM, ERIN CHRISTINE

  9. Current Pre-Doc Trainees WALLAR, GINA MARIA NAEIM, BEHNAZ

  10. 2-1. Background: Theoretical model of gene-gene/environmental interaction pathway Tobacco consumption Occupational Exposures Environmental Carcinogens / Procarcinogens Exposures Ile105Val  Ala114Val Null  Environmental Exposure GSTP1 GSTM1 CYP1A1 MspI Ile462Val  PAHs, Xenobiotics, Arene, Alkine, etc Detoxified carcinogens Active carcinogens Tyr113His His139Arg Pro187Ser Tyr113His His139Arg mEH mEH NQO1 Normal cell DNA Damage Arg194Trp, Arg399Gln, Arg280His XRCC1 M G1 G2 P53 P16 Arg72Pro Ala146Thr S Cyclin D1 G870A Programmed cell death Carcinogenesis DNA damage repaired Defected DNA repair gene If DNA damage not repaired G0 If loose cell cycle control

  11. Thank you very Much! If you have questions regarding to the possible training opportunity and application process please email your inquiry to zfzhang@ucla.edu UCLA is Equal Opportunity Employers, and minorities are encouraged to apply.

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