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THORACENTESIS and EVALUATION Prof. Dr. Remziye TANAÇ Aegean University Faculty of Medicine Division of Pediatric Allergy and Pulmonology. THORACENTESIS-PLEURACENTESIS THORACOCENTESIS. Removal of fluid from the pleural cavity through a needle,trocar or catheter.
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THORACENTESIS and EVALUATIONProf. Dr. Remziye TANAÇAegean University Faculty of MedicineDivision of Pediatric Allergy and Pulmonology
THORACENTESIS-PLEURACENTESISTHORACOCENTESIS • Removal of fluid from the pleural cavity through a needle,trocar or catheter. • Clinical-radiology: Pleural effusion • Aim: Diagnosis and treatment
THORACENTESISIt is used diagnostically to establish the cause of a pleural effusion. • Pleural effusion: Accumulation of fluid between the layers of the membrane that lines the lungs and chest cavity. The severity of the clinical picture is proportional to the size of the effusion. • Asymptomatic • Respiratory distress, dyspnea • Dry cough • Chest pain • Dullness to percussion, voice egophony
THORACENTESIS • Chest radiography: Simplest and cheap Appearance depends on the relative position of the patient • Small effusion: In supine position: Undetectable or diffuse haziness Visible fissures Blunting of the costophrenic angle (> 200-500 ml pleural fluid) Flattening, lateral displacement and elevation of the diapragm • Thoracentesis may be performed safely when a layer of at least 10 mm of fluid is present dependently on decubitus films (may be accompanied by ultrasound).
INDICATIONS of THORACENTESIS • Pleural effusion-For the Diagnosis • For the treatment of compression and dyspnea • Evaluation of intraparenchymal processes (It is unnecessary if the effusion is associated with congestive heart failure, nephrotic syndrome, ascites or recent initiation of peritoenal dialysis)
CONTRAINDICATIONS of THORACENTESIS(Not absolute it is relative) • Coagulation disorder • Anticoagulant therapy • Uremia (Creatinin>6 mg/dl) • Local infections of the performed area • An uncooperative patient
COMPLICATIONS of THORACENTESIS(14%) • Pneumothorax (5.9-19 %) • Pain at the insertion site • Bleeding • Intercostal nerve damage • Vaso-vagal response • Pleural infection • Liver, spleen damage • Air emboly • Hemothorax • Tumoral inplantation
TECHNIQUE of THORACENTESIS • Sitting position • Lateral decubitus • The patient should be supine, may have the bed elevated
TECHNIQUE of THORACENTESIS(Insertion site) Determination:Localization of the pleural fluid • Physical examination • PA and lateral radiography • Ultrasound • CT
TECHNIQUE of THORACENTESIS(Insertion site) • The upper end of the effusion of under the superior edge of the inferior rib • Anterior mid-axillary line • Distance from vertebrae 5-10cm • Preferably 5-6th intercostal space
TECHNIQUE of THORACENTESIS(Procedure) • Sterilization of the insertion site • Anesthesia to the skin, costal periost and pleura • Removal of the fluid with 25-50 heparinized syringe • Follow-up radiography
TECHNIQUE of THORACENTESIS(Procedure) • Plastic or tephlon catheter, 3-way stopcock • 350-1000-1500 ml removal of the fluid at once • Ending when pleural pressure <-20 mm H2O
EVALUATION of PLEURAL FLUID • Appearance • Biochemical examination Protein LDH Glucose Amylase Triglyceride
EVALUATION of PLEURAL FLUID • Hematologic examination Leukocyte count Hematocrit • Bacteriologic examination Gram stain Aerobic, anaerobic culture Tbc, fungal culture Ziehl-Nielson stain
EVALUATION of PLEURAL FLUID • Cytologic examination Cellular analysis • pH, PCO2
0.1-0.2 ml/kg Clear appearance pH: 7.60-7.64 Protein<1.5 g/dl Cell<1000/ ml Glucose=P glucose LDH<50% P LDH (Light RW:Ann. Intern. Med 1972;27:507-13) PLEURAL FLUID
Grossly purulent fluid Thick,tan-brown Also bloody Milky fluid Bloody Yellow-green fluid Black fluid Brown fluid Empyema, pancreatitis, esophagus ruptured S. aureus Group A streptococcus Chylothorax Hemothorax,traumatic, thoracentesis,malignancy, Tbc,uremia Rheumatoid arthritis Aspergillus nigrans Entamoeba histolyticum
PLEURAL FLUID TRANSUDATES EXUDATES
Distinguishing Exudates from Transudates(Light’s Criteria) • Pleural fluid/serum LDH>0.6 • Pleural fluid/serum protein>0.5 • Pleural fluid >2/3 serum LDH • Pleural fluid cholesterol>55mg/dl Fulfill at least one of the following criteria
TRANSUDATESResult from an imbalance of hydrostatic or oncotic pressures inflammation is absent CAUSES: Congestive Heart Failure Cirrhosis Nephrotic Syndrome Peritoneal Dialysis Urinary Obstruction Pulmonary Emboly Constructive Pericarditis Atelectasis Meigs Syndrome Hypothyroidism
EXUDATESResult from inflammation of the pleura or obstruction of lymphatic flow CAUSES: Parapneumonic effusion Connective tissue disease Tbc Malignancy Trauma Drugs Pancreatit GIS disease Chylothorax
EXUDATESCellular analysis • Neutrophilic >5000leukocytes/mm3 • Lymphocytic >50% lymphocytes (1000-1500) cells/mm3) • Monocytic >20% monocytes (<5000 cells/mm3) • Eosinophilic >10% eosinophils
Neutrophilic Predominance(Purulent Effusion) • Cell count >5000/mm3 (cell lysis occasionally results in lower cell counts) • Neutrophils predominate during the acute phase of pleural inflammation,where as lymphocytes increase in chronic phase. • Bacterial pneumonia is by far the most common cause of purulent effusions. • Differential diagnosis: Pancreatit, esophageal perforation, pulmonary infarction
Parapneumonic Effusion • 1. Exudation period (Uncomplicated) • 2. Fibropurulent priod • 3. Organization period (Complicated)
Lymphocytic Predominance >50 % Lymphocytes Differantial diagnosis • Tuberculosis • Malignancy • Connective tissue disease • Uremia
Tuberculous Effusions • Serous, serosanguinous • Glucose decreases (20-60 mg/dl) • pH 7-7.3 • Acid-fast smears (+) • ADA increases (more than 50 U/Lt) • IFN-gamma increases (more than 3.7 U/ml) • M. tuberculosis DNA-PCR
Malignancy • Leukemia • Neuroblastoma • Rhabdomyosarcoma • Ewing tm. • Lymphoma • Glucose and pH value may be normal • Pleural fluid cytology
Monocytic Effusions Viral and mycoplasma pneumoniae infections occasionally result in serous effusions caharacterized by a predominance of monocytes. • Viruses include adenovirus, influenza, herpes, varicella, measles, and cytomegalovirus. • Usually asymptomatic, are not associated with parenchymal infiltrates, and resolve without therapy. • Effusions caused by M. pneumoniae often are associated with an unilateral parenchymal infiltrate, and resolve spontaneously.
Eosinophilic Effusions • More than 10% eosinophils in pleural fluid. • Most often associated with recent pneumothorax or presence of blood in the pleural space. • Other causes: Drugs, uremia, histoplasmosis, echinococcosis, amebiasis, ascariasis, paragonamiasis, some viral infections.
Chylous Effusions • Leakage of chyle from a major lymphatic vessel into the pleural space. • Injury to the thoracic duct. • Obstruction of lymphatic channels. (Tbc, sarcoidosis, lymphoma) • Most common cause of pleural effusion in the neonatal period. • Pleural fluid triglyceride level > 110 mg/dl.
Hemothorax • 15% of all transudates are • 40% of all exudates are • Hemothorax: Pleural fluid Hct >50% of blood Hct Trauma,thrombocytopenia,malignancy, hemophilia,A.V malformation ruptured Serous-hemorragic
CONCLUSION EVALUATION of ALL DATAS ETIOLOGY of EFFUSION MANAGEMENT of THERAPY