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Case 5

Case 5. M, 78 ys Violaceous plaque on the penis History of nodal Mantle Cell Lymphoma (courtesy Prof. A. Maiorana). CD20. CD3. CD5. Bcl-6. Cyclin-D1. Mib-1. DIAGNOSIS. Cutaneous localization of Mantle Cell Lymphoma FISH: presence of t(11;14)(q13;q32). t(11;14)(q13;q32).

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Case 5

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  1. Case 5 M, 78 ys Violaceous plaque on the penis History of nodal Mantle Cell Lymphoma (courtesy Prof. A. Maiorana)

  2. CD20

  3. CD3

  4. CD5

  5. Bcl-6

  6. Cyclin-D1

  7. Mib-1

  8. DIAGNOSIS • Cutaneous localization of Mantle Cell Lymphoma • FISH: presence of t(11;14)(q13;q32)

  9. t(11;14)(q13;q32) • Translocation between IGH and cyclin D1 (CCND1) genes • It causes overexpression of CCND1 mRNA and protein cyclin D1 • Cyclin D1 overcomes the cell cycle suppressors RB1 and p27/kip1 • MCL: other secondary chromosomal aberrations

  10. Mantle Cell Lymphoma • Main differential diagnoses: • B-CLL: cyclin-D1 -; no t(11;14)(q13;q32) • B-lymphoblastic lymphoma: TdT +; CD5 -cyclin-D1 - • Blastic plasmocytoid dendritic cell neoplasm: CD4 +; CD56 +; CD123 + • Merkel cell carcinoma: CK20 +; NF +; chromogranin +

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