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Analysis of tumour stage and treatment

Analysis of tumour stage and treatment. 26 REGISTRIES IN TOTAL 2: BREAST ONLY 2: CHILDREN ONLY DATE OF INCIDENCE RANGE: 1978-2003 YEARS OF DATA RANGE: 2 TO 25 REGISTRIES VARY IN SIZE (NUMBER OF CASES) AND YEAR RANGE OF DATA. Stage and treatment data fields.

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Analysis of tumour stage and treatment

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  1. Analysis of tumour stage and treatment • 26 REGISTRIES IN TOTAL • 2: BREAST ONLY • 2: CHILDREN ONLY • DATE OF INCIDENCE RANGE: 1978-2003 • YEARS OF DATA RANGE: 2 TO 25 • REGISTRIES VARY IN SIZE (NUMBER OF CASES) AND YEAR RANGE OF DATA

  2. Stage and treatment data fields Method of diagnosis: histology, cytology, either, none or unknown Actual T, N and M data: detailed information on T, N and M status Condensed T, N and M: (more generalised information) T: localised or advanced N: none or present M: none or present Stage (Extent of Disease) combined information on tumour, nodal & distant metastasis in a single value. * possible to assign cases as local, regional or distant Tumour size in millimetres Number of nodes examined & number with metastasis Certainty factor: if specialised diagnostic methods wereused in order to stage Treatment surgery, chemotherapy, radiotherapy, other therapies (such as hormonal therapy) indicated (yes, no, unknown) Treatment flagged as first therapy post-diagnosis and/or symptomatic treatment

  3. Data available on stage and treatment

  4. Entities examined for stage and treatment: Digestive cancers: Oesophagus Stomach Small Intestine Colon, Rectum, Anal Canal Pancreas Liver and Intrahepatic Bile Ducts Gall-bladder and Extrahepatic Bile Ducts Lung cancer Breast cancer Prostate cancer

  5. Breast cancer: breakdown by sub-entity

  6. Metaplastic breast carcinoma: breakdown by Registry

  7. Lung cancer: breakdown by sub-entity

  8. Large cell carcinoma of lung: breakdown by Registry

  9. Colon cancer: Tumour T Stage validity* *codes judged invalid if they do not conform to AJCC staging protocol (Edition 1-6) Valid codes: 0, 1, 2 (2A,2B [2nd ed AJCC]), 3, 4, 5 ([1st ed AJCC])

  10. Colon cancer: Distribution of tumour T stage Average (all registries excl Ireland & Zurich): T1=7%, T2=15%, T3=60%, T4=18%)

  11. Breast cancer: Distribution of tumour T stage Average (all registries excl Ireland): T1=52%, T2=35%, T3=5%, T4=8%)

  12. Colon cancer: Tumour N Stage validity* *codes judged invalid if they do not conform to AJCC staging protocol (Edition 1-6) Valid codes: 0, 1, 2, 3

  13. Colon cancer: Distribution of tumour N stage Average (all registries excl Slovenia Cracow, Zurich, Ireland): N0=54%, N1=30%, N2=13%, N3=3%)

  14. Colon cancer: Distribution of tumour M stage Average all registries: M0=71%, M1=29%

  15. Colon cancer: Distribution of tumour M stage

  16. Summary stage (extent of disease) • 1: Tumour confined to site of origin • 2: Tumour has spread to immediately adjacent tissues and /or regional lymph nodes • 3: Tumour has spread to distant organs • 4: Tumour not confined to site of origin but not specified whether code 2 or 3 applies • 5: No distant metastasis but not specified whether code 1 or 2 applies ORDER: 1-5-2-4-3 Codes can be grouped to define a tumour as: Local (code 1) Regional (code 5+2) Distant (code 4+3)

  17. Stage (Extent of disease) for Breast cancer

  18. Stage (Extent of disease) for Breast cancer

  19. Stage (Extent of disease) for Breast cancer Stages separately

  20. Stage (Extent of disease) for Breast cancer Grouped stages

  21. Comparison of Stage 1 (tumour confined to site of origin) and TNM data (T=any, N=0, M=0) Breast cancer

  22. Comparison of Stage 3 (tumour spread to distant organs) and M=1 (positive M stage) data Breast cancer

  23. Stage (Extent of disease) for Prostate cancer

  24. Stage (Extent of disease) for Prostate cancer

  25. Breast cancer: Registries where lymph node status was examined

  26. Breast cancer: tumour size

  27. Registries that provided treatment information and years of data available 1996-1999 common to all Basque, EAnglia, WestMidlands: Codes = Yes - Unknown All Other registries: Codes = Yes - No - Unknown

  28. 1996 – 1999 Lung cancer treatment

  29. Lung cancer cases having had surgery 1996-1999 Yorkshire: 200 cases not microscopically confirmed

  30. Pancreas cancer cases having had surgery 1996-1999 EAnglia: 368 cases not microscopically confirmed

  31. Colon Cancer: Surgery 1978-2002

  32. Colon Cancer: Surgery 1978-2002

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