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But what if we test more than one locus?

But what if we test more than one locus?. The future of genetic studies of complex human diseases. Ref (Note above graphs are active spreadsheets -- just click). GRR = Genotypic relative risk. Why multiple genes? alleles?. covariance cis & trans Haplotyping Multiple loci models

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But what if we test more than one locus?

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  1. But what if we test more than one locus? The future of genetic studies of complex human diseases. Ref(Note above graphs are active spreadsheets -- just click) GRR = Genotypic relative risk

  2. Why multiple genes? alleles? covariance cis & trans Haplotyping Multiple loci models (additive, multiplicative, mean…)

  3. SNPs & Covariance in proteins Risk ratio: e2/3=0.5 ; e3/3=1; e3/4=2.5 ; e4/4=15 ApoE e4 RRR e3 RCR e2 RCC (61 112 158) Ancestral = Thr 61 Arg 112

  4. 1 72 " " Covariance in RNA ref

  5. Covariance TyC anticodon 3’acc D-stem Mij= Sfxixjlog2[fxixj/(fxifxj)] M=0 to 2 bits; x=base type xixjsee Durbin et al p. 266-8.

  6. Mutual Information ACUUAU M1,6= S = fAU log2[fAU/(fA*fU)]... CCUUAGx1x6 GCUUGC =4*.25log2[.25/(.25*.25)]=2 UCUUGA i=1j=6M1,2= 4*.25log2[.25/(.25*1)]=0 Mij= Sfxixjlog2[fxixj/(fxifxj)] M=0 to 2 bits; x=base type xixjsee Durbin et al p. 266-8. See Shannon entropy, multinomial Grendar

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