1 / 34

The Correlation Between Adolescent Major Depression Disorder and The Types Of Treatment

The Correlation Between Adolescent Major Depression Disorder and The Types Of Treatment. By Dammy Kolade Mentor: Dr. Laura Mufson. Objective.

binta
Download Presentation

The Correlation Between Adolescent Major Depression Disorder and The Types Of Treatment

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Correlation Between Adolescent Major Depression Disorder and The Types Of Treatment By Dammy Kolade Mentor: Dr. Laura Mufson

  2. Objective • I evaluated the efficiency of four treatments for adolescents with major depressive disorder: fluxentine, cognitive-behavioral therapy, their combination, and a pill placebo.

  3. Special Thanks • Mr. Francesco for guiding through this study and teaching me the skills to be able to complete this study • My parents for helping and getting me the materials I needed to complete this course

  4. Fluxentine

  5. Definitions • SRI’s or serotonin reuptake inhibitors are medications that only block serotonin. • CBT or Cognitive Behavior Therapy is the combination of two types of therapy one that identifies the problems and the other which creates solutions for the problems . Serotonin’s chemical make up

  6. Materials and Methods • In this study there will be adolescents (from ages12-17) with a primary DSM-IV diagnosis of current major depressive disorder. • The one group patients will be administered 20 or 40mg fluxentine ( based on weight and age of the patient ) a specific SRI. (serotonin reuptake inhibitors ) .

  7. Materials and Methods • The a second group of patients will administered cognitive-behavioral therapy. • Another group of patients will be administered a combination of the last two treatments (Fluxentine and CBT). • And the last group of patients were administered acutely, pill placebo.

  8. Materials and Methods • This study was a double blind placebo study . Which means that when the medicine was given out that neither I nor the patient knew is what type of medication they received .

  9. Materials and Methods • The experiment has three stages of the treatment of the patients • Stage 1 is a 12-week acute treatment period comparing four randomly assigned treatment groups: fluxentine (FLX), cognitive-behavioral therapy (CBT), their combination, and a pill placebo

  10. Materials and Methods • In stage II (6 weeks), employed a treatment extension design to ask whether higher intensity treatment in partial responders to stage I treatment was helpful. • Stage III, which lasts 8 weeks, focused on long-term maintenance of treatment gains.

  11. Materials and Methods • The 120 patients were from Columbia’s Child and Adolescent Psychiatric Department. • All the patients in the study were outpatients that went to Columbia’s Presbyterian Child and Adolescent Psychiatric Department for treatment.

  12. Materials and Methods • For responders to CBT, biweekly follow-up sessions lasted 30-50 minutes and emphasized generalization training and relapse prevention. • For partial responders to CBT, weekly visits, which lasted 50 to 60 minutes (higher dose), were tailored to the patient's needs utilizing problem-specific individual or family modules

  13. Materials and Methods • Stage II pharmacotherapy visits included biweekly or every-third-week visits, depending on response status, with responders continuing on their stage I dosing regimen. • Partial responders advanced to 60 mg FLX as tolerated beginning at the week 12 office visit.

  14. Materials and Methods • The screening process included a brief telephone interview • Followed by a visit to the clinic in which consent and assent were obtained before an evaluation of study eligibility.

  15. Materials and Methods • The patients that were given the combination of FLX and CBT that were making progress continued with the same treatment . • The patients that were making some progress had their dosages of FLX to 60 mg and their CBT to 50 to 60 minute sessions

  16. Results Demographics

  17. Results Gender Male 45.56% Female 54.44% Race/ethnicity White 73.80% African American 2.53% Hispanic 8.88%

  18. Results

  19. Results

  20. Results

  21. Results

  22. Result

  23. Results

  24. Results

  25. Results • The Table presents the percentage of adolescents who met DSM-IV criteria for other current or past psychiatric disorders. In all subjects with a coexisting psychiatric illness, MDD was determined to be the primary diagnosis and the other disorder was considered secondary to depression

  26. Results DSM-IV scores before and after the study

  27. Results • Summary Scores Mean +/- SD Median Range • CDRS-R • Total score (depression severity) 60.10 +/- 10.39 59.00 45.00-98.00 • T score (depression severity) 75.48 +/- 6.43 76.00 66.00-85.00 • CGI • CGI-S (depression severity) 4.77 +/- 0.83 5.00 3.00-7.00 • CGAS (general functioning) 49.64 +/- 7.47 50.00 32.00-80.00

  28. Results CDRS = Children's Depression Rating Scale; CGAS = Children's Global Assessment Scale • CGI = Clinical Global Impressions • RADS = Reynolds Adolescent Depression Scale

  29. Results • On the CDRS a score of (45) represents mild depression where as a score of 98 represents severe depression • On the RADS Most of the subjects fell in the moderately (40.6%) and markedly (37.8%) mentally ill categories, whereas (19.6%) adolescents were rated to be in the severely or most extremely mentally ill categories

  30. Conclusion • After analyzing the data the treatment that was most efficient was the combination of both fluxentine and Cognitive Behavioral Therapy . • When the study was finish it showed that females are two times as likely to have more severe cases of depression that males

  31. Review of Literature • American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV). Washington, DC: American Psychiatric Association • Angold A, Messer SC, Stangl D, Farmer EMZ, Costello EJ, Burns BJ (1998), Perceived parental burden and service use for child and adolescent psychiatric disorders. Am J Public Health 88:75-80 • Arias E, MacDorman MF, Strobino DM, Guyer B (2003), Annual summary of vital statistics-2002. Pediatrics 112:1215-1230

  32. Review of Literature • Ascher BH, Farmer EMZ, Burns BJ, Angold A (1996), The Child and Adolescent Services Assessment (CASA): description and psychometrics. J Emot Behav Disord 4:12-20 • Beck AT, Steer RA (1993), Manual for the Beck Hopelessness Scale (BHS). San Antonio, TX: The Psychological Corporation • Beck AT, Steer RA, Brown GK (1996), Manual for the Beck Depression Inventory-II. San Antonio, TX: The Psychological Corporation • Brent DA, Moritz G, Bridge J, Perper J, Canobbio R (1996), The impact of adolescent suicide on siblings and parents: a longitudinal follow-up. Suicide Life Threat Behav 26:253-259 • Brent DA, Holder D, Kolko D et al. (1997), A clinical psychotherapy trial for adolescent depression comparing cognitive, family and supportive therapy. Arch Gen Psychiatry 54:877-885

More Related