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CSOPS Engineering Research Center on Structured Organic Particulate Systems

Team Goal. To create a tabletop pharmaceutical manufacturing line to educate students K-12 on the production of dry pharmaceutical products. Individual Projects. Blending Create a V-blender to mix the powder to a uniform contentRoller CompactionUsed to increase the particle size of the materialM

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CSOPS Engineering Research Center on Structured Organic Particulate Systems

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    1. CSOPS Engineering Research Center on Structured Organic Particulate Systems

    2. Team Goal To create a tabletop pharmaceutical manufacturing line to educate students K-12 on the production of dry pharmaceutical products

    3. Individual Projects Blending Create a V-blender to mix the powder to a uniform content Roller Compaction Used to increase the particle size of the material Milling

    4. Powder Blending Pharmaceutical products contain API (Active pharmaceutical ingredients) and fillers Each tablet needs to have the same amount of API to ensure quality in the drug

    5. Project Goals To have an operating V-blender that will help educate students K-12 by the end of the semester To have to blender be completely controlled and operated automatically (Senior Design)

    6. Scope The scope encumbaces: The physical structure Powder material Automation User interface Safety

    7. Timeline

    8. Design (CAD Drawing)

    9. Current Phase We are currently working on attaching the blender to the support structure The design of the pulley/gear system is in progress

    10. Automation and Control (Senior Design)

    11. What is next? We need to design the gear and pulley system and put the automation into the physical structure Work on enclosing all moving parts for safety Improve aesthetics of the project and prepare for delivery.

    12. Mill Anna Harlan, Dan Prystawsky, Winnie Tan, Megan Benadum

    13. Background Milling Process – The purpose of milling in the pharmaceutical process is to take the product from compacting and make it (the product) ready to be taken to the tablet stage. The milling process consists of: Making the compacted particles into the correct size for the rest of the process. Making the compacted product into a more consistent product. (When the granules come out of the milling process they are very similar in size and shape to each other.)

    14. Background Things to take into account when designing a mill: Way of entry from compactor Way to exit materials from machine Size/Amount of entering material Visibility to students (educational purpose) Desired exit material’s size Materials being milled

    15. Project Goals The milling team will: Teach children from kindergarten to high school the milling process in pharmaceuticals. This will be accomplished by building a working replica of a mill The mill will be part of a table top pharmaceutical process

    16. Scope of the Project This project deals with the mill only We are in contact with the roller compacting group about how the material will be coming to us The design is small, around 5 inches in diameter and 12 inches tall total

    17. Timeline

    18. Design Specifications Small enough to fit the ‘table top’ design Clear parts to see in on what is happening Motor to run impeller at 500 rpm (700 in pharmacy building) Funnel at bottom to collect milled powder in a cup

    19. Future Work Detailed design approval List of materials needed for design Purchase materials Building of the mill

    20. Roller Compaction

    21. Members Pavan Revankar - ACT Freshman, 1st semester with CSOPS Jonathan Scales - ME Sophomore, 1st semester with CSOPS Dale Szul - ME Sophomore, 1st semester with CSOPS Tony Stoeger - CEM Sophomore, 2nd semester with CSOPS

    22. Overview Used in conjecture with pharmaceutical milling Material which passes through rollers is compressed into ribbon/sheets Both rollers rotate towards one another with one roller being pushed into the other Usually a few millimeter gap in between the rolls during compaction

    23. Goals Demonstrate the system to K-12 grade students to further understanding of the engineering processes in pharmaceuticals. To create a final product based upon considerations of many conceived design options

    24. Scope of Project Deliverables Our final product Journal documentation Operation Manual Outcomes Working educational tool

    25. Timeline 8/20-9/12: Conceptual Design Identifying customer requirements Identifying goals/expected deliverables 9/12-present: Detailed Design Searching for parts Reverse Engineering

    26. Design Progress Using batch-process: Designed rollers according to size of batch process (500-1000cm3) Two rotating rollers, one fixed and one horizontally adjustable (based on pressure) Roller material: steel (machined) Horizontal pressure supplied by a car jack Funnel/Hopper material feed to rollers

    27. Current Phase Finishing up the detailed design phase Motor Specifications: require T = 170 N*m, about <10 rpm Researching a gearbox to meet above specs. Researching bearings for rollers Consider how roller spindles are compatible with the gearbox

    28. What is Next? Finishing the Design Phase Selecting and ordering a motor and gearbox Consider our mounting options

    29. Setbacks Team too small Lack of EE’s (none) Lack of upperclassmen Members quitting Limited budget

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