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BIPN 148 Lecture 16

BIPN 148 Lecture 16. Remembering Jennifer Anniston. Activate Visual and Auditory Neurons. Stimulate Hippocampal Neurons. Get info from cortex to hippocampus. Somatosensory. Visual. Olfactory. Sensory Regions Of Cortex. Auditory. Perirhinal Cortex. Perirhinal/ Entorhinal Cortex.

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BIPN 148 Lecture 16

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  1. BIPN 148 Lecture 16

  2. Remembering Jennifer Anniston

  3. Activate Visual and Auditory Neurons

  4. Stimulate Hippocampal Neurons

  5. Get info from cortex to hippocampus Somatosensory Visual Olfactory Sensory Regions Of Cortex Auditory Perirhinal Cortex Perirhinal/ Entorhinal Cortex Entorhinal Cortex CA3 Hippocampal Formation Dentate Gyrus CA1

  6. Stimulate hippocampal synapses

  7. Activate Spines

  8. Potentiate Synapses

  9. Activate CaMKII

  10. Phosphorylate AMPA receptors

  11. Phosphorylate GluR1on S831

  12. Insert GluR1 at synapses

  13. Unsilence synapses

  14. Use Stargazin to traffic AMPA-R Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.

  15. Induce gene expression

  16. Use CaMKIV to induce gene expression

  17. Express new genes CaMKIV + ERK RSK2 Elk-1 CBP/CREB zif268 CRE SRE C/EBP krox20 Arc AMPAR HOMER BDNF NT-3

  18. Send gene products to synapse New gene products or proteins New gene products or proteins Synaptic tag NMDAR Signal to nucleus Synaptic Potentiation Locally generated tag captures new gene product

  19. Remembering Jennifer Anniston Activate visual & auditory neurons Stimulate hippocampal neurons Change synaptic strength by inserting AMPA receptors Induce gene expression Stabilize change in synaptic strength Recall image with visual cue Don’t confuse with Angelina Jolie

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