New SARMS Most Reliable? BMS-564929? Powder Supplier Online

1. www.aasraw.com New SARMS Most Reliable BMS-564929 Powder Supplier Online New SARMS Most Reliable BMS-564929 Powder Supplier Online...............................1 1. New Sarms & BMS-564929 & CAS: 627530-84-1........................................................................... 1 2. BMS-564929 Powder.......................................................................................................................3 3. BMS-564929 Powder & Biological Activity..................................................................................... 4 4. References on BMS-564929 powder(CAS: 627530-84-1)...............................................................5 (1) Detection of SARMs in doping control analysis.....................................................................5 (2) Mass spectrometry of hydantoin-derived selective androgen receptor modulators.......... 7 5. SARMS BMS-564929 Powder Supplier............................................................................................8 6. Buy BMS-564929 powder online--AASraw...................................................................................10 7. Related SARMS Powder.................................................................................................................12 1. New Sarms & BMS-564929 & CAS: 627530-84-1 BMS-564929 is an investigational selective androgen receptor modulator, CAS: 627530-84-1 is being developed by Bristol-Myers Squibb for treatment of the symptoms of age-related decline in androgen levels in men (“andropause“). These symptoms 1 aas11@aasraw.com

2. www.aasraw.com may includedepression, loss of muscle mass and strength, reduction in libido and osteoporosis. Treatment with exogenous testosterone is effective in counteracting these symptoms but is associated with a range of side effects, the most serious of which is enlargement of the prostate gland, which can lead to benign prostatic hypertrophy and even prostate cancer. This means there is a clinical need for selective androgen receptor modulators, which produce anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in the prostate. BMS-564929 is one such compound currently in early human clinical trials, CAS: 627530-84-1 is an orally active, potent and selective agonist for androgen receptors (Ki 2.1nM, 20x functional selectivity for muscle tissue over prostate) and in studies on castrated rats BMS-564929 was shown to counteract decrease in muscle mass over time, and at higher doses even increased muscle mass, without significantly affecting prostate tissue.It does however vastly reduce luteinizing hormone levels, it being an astonishing 33x more suppressive compound than testosterone,which may be a problem in human clinical use. 2 aas11@aasraw.com

3. www.aasraw.com Selective androgen receptor modulators may also be used by athletes to assist in training and increase physical stamina and fitness, potentially producing effects similar to anabolic steroids but with significantly fewer side effects. For this reason, SARMs have already been banned by the World Anti-Doping Agency since January 2008 despite no drugs from this class yet being in clinical use, and blood tests for all known SARMs are currently being developed. 2. BMS-564929 Powder Product Name BMS-564929 powder CAS Number 627530-84-1 Appearance Solid powder Purity >98% (or refer to the Certificate of Analysis) Shipped under ambient temperature as non-hazardous Shipping chemical. This product is stable enough for a few weeks Condition during ordinary shipping and time spent in Customs. Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 Condition C for long term (months to years). 3 aas11@aasraw.com

4. www.aasraw.com Shelf Life >2 years if stored properly Drug This drug may be formulated in DMSO Formulation 3. BMS-564929 Powder & Biological Activity ♦ BMS-564929 powder is a novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator (Ki= 2.11 nM). ♦ IC50: 2.11 ± 0.16 nM (Ki value), CAS: 627530-84-1. ♦ Target: Androgen receptor BMS-564929 powder has been advanced to clinical trials for the treatment of age-related functional decline. BMS-564929 is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. ♦ In vitro: BMS-564929 powder is a high affinity ligand for AR with a Ki of 2.11 ± 0.16 nM. This compound is more than 1000-fold selective for AR vs. ER? and ?, GR, and MR, and approximately 400-fold selective vs. PR . BMS-564929 powder exhibited a potency (EC50, calculated as the concentration at which 50% of the maximum stimulatory effect of DHT is 4 aas11@aasraw.com

5. www.aasraw.com achieved) of 0.44 ± 0.03 nM compared with 2.81 ± 0.48 nM measured for T in the C2C12 myoblast cell line. Sample preparation based on solid-phase extraction and subsequent LC-MS/MS measurement allowed for detection limits of 1-20 ng/mL, intra- and interday precisions of between 2.4 and 13.2% and between 6.5 and 24.2%, respectively. ♦ In vivo: The compound was administered across a wide dose range (1 ?g to 1 mg/kg) for 8 wk in the same recovery schedule of administration as the 2-wk experiments. A dose-dependent increase in levator ani muscle and prostate wet weight was observed with BMS-564929 powder treatment, with ED50 values of 0.001 and 0.09 mg/kg for the levator ani and prostate, respectively. 4. References on BMS-564929 powder(CAS: 627530-84-1) (1) (1) Detection Detection of of SARMs SARMs in in doping doping control control analysis analysis The class of selective androgen receptor modulators (SARMs) has been the subject of intense and dedicated clinical research over the past two decades. Potential therapeutic applications of SARMs are manifold and focus particularly on the treatment of conditions manifesting in muscle loss such as general sarcopenia, cancer-associated cachexia, muscular dystrophy, etc. Consequently, based on the substantial muscle- and bone-anabolic 5 aas11@aasraw.com

6. www.aasraw.com properties of SARMs, these agents constitute substances with significant potential for misuse in sport and have therefore been added to the Word Anti-Doping Agency's (WADA's) Prohibited List in 2008. Since then, numerous adverse analytical findings have been reported for various different SARMs, which has underlined the importance of proactive and preventive anti-doping measures concerning emerging drugs such as these anabolic agents, which have evidently been misused in sport despite the fact that none of these SARMs has yet received full clinical approval. In this review, analytical data on SARMs generated in the context of research conducted for sports drug testing purposes are summarized and state-of-the-art test methods aiming at intact drugs as well as diagnostic urinary metabolites are discussed. Doping control analytical approaches predominantly rely on chromatography hyphenated to mass spectrometry, which have allowed for appropriately covering the considerable variety of pharmacophores present in SARMs such as the non-steroidal representatives ACP-105, BMS-564929 powder, GLPG0492 (DT-200), LG-121071, LGD-2226, LGD-4033/VK 5211, ostarine/enobosarm, RAD-140 powder, S-40503, etc. as well as steroidal compounds such as MK-0773 and YK-11. 6 aas11@aasraw.com

7. www.aasraw.com (2) (2) Mass Mass spectrometry spectrometry of modulators modulators of hydantoin-derived hydantoin-derived selective selective androgen androgen receptor receptor N-Aryl-hydroxybicyclohydantoins represent a new class of tissue-selective anabolic agents [selective androgen receptor modulators (SARMs)] and are promising therapeutics as well as drugs prohibited in amateur and professional sport. The dissociation behavior after negative and positive electrospray ionization (ESI) and subsequent collision-induced dissociation (CID) was studied with a drug candidate (BMS 564929 powder) as well as structurally related and isotope-labeled analogs using high resolution/high accuracy orbitrap mass spectrometry. Positive ionization and CID yielded characteristic product ions resulting from the cleavage of the hydantoin structure providing information about the proline-derived nucleus as well as the substituted aryl residue at m/z 96 and 193, respectively. Negative ESI and 7 aas11@aasraw.com

8. www.aasraw.com CID (MS/MS) yielded product ions mainly representing losses of water and CO(2), the latter of which is of particular significance as the hydantoin structure does not contain a carboxyl function. Employing MS(n) experiments with accurate mass determination on six model SARMs, dissociation pathways to characteristic product ions were proposed supporting the identification of these drugs, their metabolites or related compounds in future doping control assays. 5. SARMS BMS-564929 Powder Supplier Maybe we're barking up the wrong tree, but we think we've found it: the mysterious SARM that the Cambridge-based pharmaceuticals company Radius is doing tests on. The structural formula is shown in the diagram below. We came across it in Tetrahedron Letters, in an article that suggests that this substance has powerful anabolic effects. There are other BMS-564929 powder suppliers working on SARMs too, like Radius. In Tetrahedron Letters Radius researchers describe the synthesis of a compound with the unpronounceable name (2R, 3S) 2-amino 3-(benzyloxy) 8 aas11@aasraw.com

9. www.aasraw.com 4,4,4-trifluorobutanoic acid (4,4,4-trifluoro-OBn-D-allothreonine). In the article the researchers refer to the compound simply as compound 7 [cpd 7], which is the molecule in the diagram above. Many BMS-564929 powder suppliers suspect that compound 7 is capable of interacting with the androgen receptor, so they tested it on rats. LABC = levator ani muscle, a marker for desired anabolic effects; Prostate = the weight of the prostate, a marker for undesired androgenic effects. Compound 7 works better than testosterone propionate, as you can see. Interestingly though, the researchers gave the rats compound 7 orally, while they injected the testosterone. BMS-564929 powder dose they gave is modest, for a SARM at least. All things considered, compound 7 seems to resemble another promising SARM, BMS-564929 powder, which is produced by Bristol-Myers Squibb. BMS-564929 powder dosing has been a major concern, and many researchers are elaborating on it.Many BMS-564929 powder suppliers have not been able to provide the BMS-564929 powder dose. 9 aas11@aasraw.com

10. www.aasraw.com Radius is now doing tests with a SARM that it has labelled RAD140. It is "potentially the first orally administered anabolic drug for treating osteoporosis, sarcopenias, and frailty associated with aging", Radius claims on its website. 6. Buy BMS-564929 powder online--AASraw BMS-564929 powder is a highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator. BMS-564929 powder is a subnanomolar AR agonist in vitro, is highly selective for the AR vs. other steroid hormone receptors, and exhibits no significant interactions with SHBG or aromatase. Dose response studies in castrated male rats show that BMS-564929 powder is substantially more potent than testosterone (T) in stimulating the growth of the levator ani muscle, and unlike T, highly selective for muscle vs. prostate. 10 aas11@aasraw.com

11. www.aasraw.com At present, a large number of BMS-564929 powder suppliers are arranging the production of BMS-564929 powder. There have been many publicity websites on the market, hoping to seize the market of BMS-564929 powder ahead of time.It is understood that AASraw, which currently occupies the technical and quality advantages, has started to supply BMS-564929 powder to the market. For more details, please refer to the official website of AASraw. Visit our AASraw web sit: www.aasraw.com. If you wan to buy BMS-564929 powder now, then do as below steps one by one: ♣ To contact us by our email inquiry system,or online skypecustomer service representative(CSR). ♣ To provide us your inquired quantity and address. ♣ Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA). ♣ Payment done and the goods will be sent out in 12 hours(For order within 10kg). 11 aas11@aasraw.com

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