solid phase phosphoramidite chemistry

1. Common RNA Synthesis With many years of experience in engineered nucleic acid production, BOC RNA has accumulated a wealth of phosphoramidite technology expertise in protection chemistry, modification, production scale-up, and innovative purification strategies. We provide high-quality phosphoramidites for RNA oligonucleotide synthesis. All standard (and customized) phosphoramidite production is strictly controlled by process and quality. Our phosphoramidite products include RNA phosphoramidites, 2’-OMe- phosphoramidites, 2’-F-phosphoramidites, 2’-MOE-phosphoramidites, 3’-TBDMS- RNA phosphoramidites, 5-modified phosphoramidites, etc. Phosphoramidites Features Ideal for synthesis therapeutic (and research) high-fidelity oligonucleotides, such as gene synthesis, gene editing, CRISPR-cas9 gRNA, antisense (ASO), and siRNA. RNA phosphoramidites  2’-OMe-phosphoramidites 2’-F-phosphoramidites Used to help increase the stability of oligonucleotides and increase resistance to nuclease activity in the body. Supporting a variety of nucleic acid-based applications such as antisense, siRNA, gene design and genome editing, including CRISPR-cas9 gRNA.  2’-MOE-phosphoramidites  3’-TBDMS-RNA phosphoramidites 5-modified phosphoramidites Quality control The entire process is monitored from material procurement to final quality control and product release, providing repeatability and security between batches Assess purity of each RNA phosphoramidite batch by HPLC and 31 P NMR The tightly controlled manufacturing process ensures minimal levels of impurities   

2. Custom services Custom manufacturing services available to help develop or expand phosphoramidite compounds Products for RNA synthesis https://rna.bocsci.com/products-services/common-rna-synthesis.html