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Research at UT College of Dentistry

Research at UT College of Dentistry. Alumni Board Meeting March 6, 2013. In Greek mythology, a  phoenix or phenix. is a long-lived bird that is cyclically regenerated or reborn. . S ymbolizes renewal in general . Franklin Garcia-Godoy, DDS, MS, PhD, PhD

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Research at UT College of Dentistry

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  1. ResearchatUT College ofDentistry • Alumni Board Meeting • March 6, 2013

  2. In Greek mythology, a phoenixor phenix is a long-lived bird that is cyclically regenerated or reborn.  Symbolizes renewal in general 

  3. Franklin Garcia-Godoy, DDS, MS, PhD, PhD • Professor and Senior Executive Associate Dean for Research • Director, Bioscience Research Center Dental Research

  4. Dedicated research faculty State-of-the-art research centers Exceptional students A dental research program built on :

  5. Goal

  6. July 1, 2012 to June 30, 2013: • 11 New Grants • 115 New Publications (65 last year) • 23 Students in Summer Research Fellowship (18 last year) • Renovation and new equipment Bioscience Research Center • & Clinical Research Center Summary

  7. 28 active grants: • 5 Federal (2 new) • 1 Foundation • 7 Sponsorships (6 new) • 18 Alumni Endowment (8 new) • 15 submitted grants: • 4 Federal • 1 Foundation • 4 Sponsorship • 3 Alumni Endowment Grants

  8. Grants

  9. Grants

  10. Since 2009 the College has received almost • $3,000,000 • In federal, industrial and foundation grants! Faculty PublicationsMay 2009 – March 2013

  11. There were 65 publications in FY 2012 and >90 in FY 2013. Publications

  12. Student ResearchSummer 2012 Amanda Hindsman, winner of the Student Clinician Award, Student Research Day 2012 Ashley Jones, works on her summer research project in the Craniofacial Research Center Alexander Garcia-Godoy, winner of the Harold Cloogman Award for Best Summer Research Project

  13. Students in Research Student Summer Research Program (funded by the Alumni Endowment for Research and TDAF) No. Students in Program: Summer 2013: 20 Summer 2012: 23 Summer 2011: 18 Summer 2010: 14 Summer 2009: 12

  14. Student Presentations Hinman Student Research Symposium 2012

  15. Students in Research Hinman Student Research Symposium Annual student research event, hosted by the University of Tennessee College of Dentistry, held at the Peabody Hotel (Memphis, TN) Hinman 2012 October 26-28, 2012 No. Schools: 45* (48) No. Students: 101 (86) UT Students: 20 (14) *Representing 28 states, the District of Columbia, and 3 Canadian provinces.

  16. Students in Research UTHSC Student Research Day Annual student research event, hosted by College of Dentistry for dental students. Student Research Day 2013 February 12, 2013 No. Students: 41 (31) Tyler Allen (D-3) awarded Student Clinician Award for most outstanding clinical presentation, “Evaluation of the Precision, Accuracy, and Efficiency of Virtual Electronic Dental Models Using Bolton Analysis.” (Faculty mentors: Drs. T. Trojan, E.F. Harris, M. Scarbecz)

  17. Laurel Meriwether (D-3) Megan Moshea (D-4) Amanda Hindsman (D-3) Student Presentations at the IADR Annual Meeting 2013 Drew Mallard (D-3) Mariam Habib (D-3) Alexander Garcia-Godoy (D-4)

  18. . • Antimicrobial Efficacy of Non-Thermal Plasma on Viability of Oral Bacteria A.H. JOHNS1, J. BABU1, F. YANG1, L. HONG1, M. CHEN2, and Q. YU3, 1Bioscience Research , College of Dentistry, UTHSC, University of Tennessee, Memphis, TN, 2Nanova, Inc, Columbia, MO, 3Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO • Galectin-1 in Cultured OSCC and Control Cells J.R. KNITTEL, College of Dentistry, University of Tennessee, Memphis, TN, M.M. JEFFERSON, University of Tennessee Health Science Center, Memphis, TN, E. THOMAS, Bioscience Research, University of Tennessee Health Science Center, Memphis, TN, and M. DABBOUS, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN • Antimicrobial Effects of Non-thermal Atmospheric Plasma as a Canal Disinfectant M. HABIB1, T. HOTTEL2, J. BABU3, F. GARCIA-GODOY2, F. YANG4, and L. HONG1, 1University of Tennessee, Memphis, TN, 2College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 3Bioscience Research, University of Tennessee, Memphis, TN, 4Pediatric and Community Dentistry, University of Tennessee Health Science Center, Memphis, TN • Toothbrushing With A Novel Dentifrice On Porcelain Roughness And Gloss A. GARCIA-GODOY, Bioscience Research, University of Tennessee, Cordova, TN, F. GARCIA-GODOY, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, R.R. WICKS, Prosthodontics, University of Tennessee, Memphis, TN, B. MORROW, Bioscience Research, University of Tennessee, Memphis, TN, and L.M. KAO, LMKAO LLC, New York, NY • Effect of Gingival Retraction Materials on Dentin Shear Bond Strength E.K. SWENSON1, J.F. SIMON DDS1, D. TANTBIROJN2, and A. VERSLUIS3, 1University of Tennessee Health Science Center, Memphis, TN, 2Department of Restorative Dentistry, University of Tennessee Health Science Center, Memphis, TN, 3Bioscience Research, University of Tennessee Health Science Center, Memphis, • Antibacterial Activity of Dental Adhesive System: An in vitro study J. TUCKER, F. GARCIA-GODOY, D. TIPTON, and J. BABU, Bioscience Research, University of Tennessee, Memphis, TN Student Presentations (9) at theIADR/AADR Annual Meeting 2013

  19. .Porphyromonasgingivalis Infection Modifies Host Cell Proteins R.N. ANDERSON1, D.A. TIPTON1, and M. RADIC2, 1College of Dentistry, University of Tennessee, Memphis, TN, 2College of Medicine, University of Tennessee, Memphis, TN • Cranberry Effects on AGE-stimulated IL-6 and MMP-3 Production by Fibroblasts A.A. HATTEN, D.A. TIPTON, and J.P. BABU, Bioscience Research, University of Tennessee, Memphis, TN • Effects of Non-thermal Plasma on Oral Bacterial Biofilm in Vitro T. LIU1, J. BABU1, L. HONG1, M. CHEN2, and Q. YU3, 1University of Tennessee, Memphis, TN, 2Nanova Inc, Columbia, MO, 3Department of Mechanical & Aerospace Engineering, University of Missouri-Columbia, Columbia, MO The Student Summer Research Program is funded by the UT Dental Alumni Endowment and the Tennessee Dental Association Foundation Student Presentations at theIADR/AADR Annual Meeting 2013

  20. Dr. George Huang, DDS, MSD, DScis Professor and Director of Stem Cells and Regenerative Therapies. Dr. Huang is a world-renowned boarded endodontist, specializing in the regeneration of bone using dental pulp. • Dr. Yanhui Zhang, PhD is a new assistant professor in the Department of Bioscience Research, currently conducting product tests for plaque glycolysis and regrowth, and saliva biomarkers • Dr. Chris Ivanoff, DDS is a new associate professor in the Department of Bioscience Research, specializing in alternate current electrokinetics and dielectrophoretic drug transport in dentistry. • . New Research Faculty

  21. George Huang, DDS, MSD, DSc is Professor and Director of Stem Cells and Regenerative Therapies, Department of Bioscience Research Dr. Huang is a world-renowned boarded endodontist, specializing in the regeneration of bone using dental pulp. • . New Book

  22. Franklin Garcia-Godoy, DDS, MS, PhD, PhD is Professor and Senior Executive Associate Dean for Research Chair, Department of Bioscience Research Director, Bioscience Research Center • . New Book

  23. UT Memphis – November 2009

  24. Bioscience Research Center Photos taken June 30, 2011

  25. UT Memphis – November 2012

  26. UT Memphis – March 2013

  27. The Clinical Research Center, located on the 3rd floor of the Dental Building, will be used for industry-sponsored clinical trials. There are already three clinical studies being conducted in the center. TheClinical Research Center

  28. 14 grants were submitted • Category I Research Grants • 14 grants were recommended to the Dean • 14 grants are recommended to the Alumni These grants would be awarded August 1, 2013. Alumni Endowment Grants (April 2013)

  29. 1 grant was submitted • Category I Research Grants • 1 grant was recommended to the Dean • 1 grant was presented at the Mid-South Meeting and approved The grant was funded and will begin August 1, 2013 Alumni Endowment Grants (October 2012)

  30. 115 new publications! • (A record in the Dental School) Faculty PublicationsJuly 1, 2012 – July 1, 2013

  31. 29 presentations! • (A record in the Dental School) IADR MeetingSeattle, March 21-23, 2013

  32. Research Presentations at IADR Meeting, Seattle, 2013 By Nationally-Ranked Research Dental Schools

  33. Research Presentations at IADR Meeting, Seattle, 2013 By Dental Schools in the Mid-South U.S.

  34. Dental materials • Dental plaque glycolysis • Testing of toothbrushes, toothpastes, and mouthrinses (in vitro and in vivo) • Demineralization/remineralization of dental tissues • Dental erosion • Stem cells and regenerative therapies • a. Stem cell mediated regenerative endodontics • b. Neurogenesis using adult and iPS cells • c. Genetic profiles in stem cells of oral vs dermal origin • Biocompatibility/cytotoxicity/genotoxicity • Implant coatings • Development of a mouse P gingivalis-induced periodontitis model on a humanized HLA/DR1 mouse model susceptible to rheumatoid arthritis. Is genetic susceptibility to periodontitis associated with genetic susceptibility to rheumatoid arthritis? • Susceptibility to bisphosphonate-induced osteonecrosis by genomic analysis in a mouse model. • The effect of Resveratrol and its compounds on human gingival epithelial and squamous cell carcinoma cells. • Osteogenic potential of PDL stem-like cells in periodontal health and disease. • Regulation of tooth mineralization by the bone proteins PHEX and DMP1 in an hypophosphatemic mouse model. • Malocclusion in rodent models: genetic background and dental hard tissues density and hardness. • Clinical research Key areas of ResearchJuly 2012 – July 2015

  35. Future Plans • Short-Term Goals (FY2013) • Complete dental school laboratory (Bioscience Research Center) and Clinical Research Center. • Long-Term Goals (FY2013-FY2023) • Develop the plaque glycolysis, demineralization/remineralization and dental erosion laboratory capabilities in the newly developed lab to increase industrial funding. • Increase clinical research projects and funding in the newly developed Clinical Research Center.

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