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Supplementary figs

Supplementary figs. B Rucaprib uptake is not sodium dependent. S1. A [ 14 C] rucaprib accummulation in SW620 cells. C Rucaprib retention is associated with prolonged PARP inhibition. S2 Rucaparib metabolite PK. A. B. S2C.

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Supplementary figs

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  1. Supplementary figs

  2. B Rucaprib uptake is not sodium dependent S1 A [14C] rucaprib accummulation in SW620 cells C Rucaprib retention is associated with prolonged PARP inhibition

  3. S2 Rucaparib metabolite PK A B

  4. S2C

  5. Supplementary Table 1. Satellite rucaparib PK-PD in Capan-1 tumour-bearing mice Grey shading means values outside the standard curve.

  6. S3 A

  7. S3 B

  8. S3 C

  9. S3 D MX-1 study mouse weights

  10. S3 E Satellite PARP inhibition in MX-1 xenografts and liver 24 hr after single dose

  11. S3F

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