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Weight Management Gene Expression Science

Weight Management Gene Expression Science. Advances in Gene Expression Science Allow Scientists to Compare & Contrast Expression Patterns of two Biological States. Biological State #1. Biological State #2 State. Animation Place Holder.

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Weight Management Gene Expression Science

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  1. Weight Management Gene Expression Science

  2. Advances in Gene Expression Science Allow Scientists to Compare & Contrast Expression Patterns of two Biological States • Biological State #1 • Biological State #2 State Animation Place Holder

  3. Comparison of Genetic Profiles of Adipose Tissue in Identical Twins Pietiläinenet al. PLoSMed. 2008 Mar 11;5(3):e51. Overweight Twin Normal Weight Twin Same DNA Different Expression of Genes Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to: • Fat Regulation (storage versus utilization) • Muscle Protein Synthesis

  4. Deep understanding of gene expression science • Nu Skin owns patented technologies to study anti-aging interventions through gene expression science

  5. Identified Gene Expression Pathways Linked to • Fat Storage and Fat Metabolism FAT STORAGE FAT BURN LifeGen pre-clinical study of Adipose, Gastrocnemiusmuslce, Hypothalamus

  6. Gene Expression relates to the Appetite Control Center of the Brain • Appetite Control • Eating Behavior • Regulation of energy intake Ghrelin • Leptin • Insulin References: • Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. • Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. • De Silva, et al. Cell Metab. 2011;14:700-706. • Malik S, et al. Cell Metab. 2008;7:400-409. • Farooqi IS, et al. Science. 2007;317:1355 • Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. • Viquerie N, et al. Diabetologia. 2005;48(1):123-131. • Mager et al. European Journal of Endocrinology. 2008;158: • Mutch DM, et al. Am J ClinNutr. 2011;94(6):1399-1409.

  7. Formulations Based on: • Proprietary gene Expression Research • The latest and most robust nutritional science

  8. Eating Plan Based on: • Protein Science & Nutrition Science • An eating plan designed to complement the supplements. • Supports metabolically-active lean muscle and inhibits fat storage1 Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.

  9. Typical Reduced Calorie Diet – 2000 kcal Proteins (90g) Carbohydrates (260g) Fat Burning Foods Proteins (90 g) Fat Storing Foods Carbohydrates (260 g) Fats (67g) Fat Storing Foods Fats (67 g)

  10. Typical Reduced Calorie Diet – 2000 kcal – 1200 kcal Proteins (90g) Carbohydrates (260g) Fat Burning Foods Proteins (45 g) Fat Storing Foods Carbohydrates (180 g) Fats (67g) Fat Storing Foods Fats (33 g)

  11. Eating Plan – 1200 kcal Proteins (90g) Carbohydrates (260g) Fat Burning Foods Proteins (90 g) Fat Storing Foods Carbohydrates (260 g) Fats (67g) Fat Storing Foods Fats (67 g)

  12. Eating Plan – 1200 kcal Proteins (90g) Carbohydrates (260g) Fat Burning Foods Proteins (90 g) Fat Storing Foods Carbohydrates (120 g) Fats (67g) Fat Storing Foods Fats (40 g)

  13. Eating Most of Your Protein with Only One Meal of the DayLimits Duration of Metabolic Burn Time in Metabolic Burn Zone = Only 3 hours/day FAT BURNING ZONES FAT STORING Breakfast Lunch Dinner Adapted from: Paddon-Jones and Rassmussen. CurrOpinClinNutrMetabCare, 2009;12:86. Layman DL. Nutrition and Metabolism, 2009; 6:12.

  14. Eating Protein with Each Meal Accelerates Metabolic Burn Time in Metabolic Burn Zone = 9 hours/day FAT BURNING ZONES FAT STORING Breakfast Lunch Dinner Adapted from: Paddon-Jones and Rassmussen. CurrOpinClinNutrMetabCare, 2009;12:86. Layman DL. Nutrition and Metabolism, 2009; 6:12.

  15. Open Label Clinical Study • 90 Days on ingredients-based program • 45 women and 21 men completed the study • Participants Reported… • Lower levels of Hunger • Changes in body silhouette • Clothes fit better • Liked this program better than programs they had tried previously Results of unpublished preliminary study 2013

  16. ageLOCTR90 Summary • Healthy weight management and Body Shaping program. • Based on gene expression science, addresses key factors related to weight management: • Healthy Metabolism, • Promotes Lean Muscle Maintenance • Appetite Control • Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.

  17. NutritionScience Antioxidant Science Gene ExpressionScience SIGNS & SYMPTOMS

  18. LIFEPAK—THE PERFECT COMPANION • Nutritional foundation is important • LifePak® provides that foundation • Ensure adequate nutrition during reduced calorie regimen • Dietary antioxidants for added protection from oxidative stress

  19. LifePak Off-sets Oxidative Stress During Dieting • Participants took LifePak • Scanner Scores increase an average of 6,000 per person 40,000 36,000 30,000 30,000 29,000 Average SCS for study participants 20,000 10,000 Baseline 6 Weeks 12 Weeks Data from My Victory Open-label Study 2007

  20. AGELOC R2 – The Perfect Companion • Maintain energy levels • Assist with cell renewal and cleansing during lipolysis

  21. TR90 SUPPORT TOOLS

  22. What’s your Transformation Number? Ninety nine Createand communicate your personal transformation through a compelling story and transformation number that is completely unique to your ageLOC TR90 experience.

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