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A. D. HBSS. HBSS. Caffeine. Caffeine. Caffeine. Caffeine. 4. 100. 3. F/F 0. Airway area (% initial area). 80. 2. 1. 60. 0. 5. 10. 15. 0. 2. 8. 10. Time (min). Time (min). B. E. FSK. FSK. Caffeine. Caffeine. Caffeine. Caffeine. 4. 100. 3. F/F 0.

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  1. A D HBSS HBSS Caffeine Caffeine Caffeine Caffeine 4 100 3 F/F0 Airway area (% initial area) 80 2 1 60 0 5 10 15 0 2 8 10 Time (min) Time (min) B E FSK FSK Caffeine Caffeine Caffeine Caffeine 4 100 3 F/F0 Airway area (% initial area) 80 2 1 60 0 5 10 15 0 2 8 10 Time (min) Time (min) C F 1.2 1.0 1.0 0.8 0.8 0.6 0.6 Airway contraction Fluorescence intensity (ratio to the 1st Caffeine effect) (ratio to the 1st Caffeine effect) 0.4 0.4 0.2 0.2 0.0 0.0  FSK + FSK + FSK  FSK

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