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Chapter 10- Benzodiazepines

Chapter 10- Benzodiazepines. Anti-Anxiety. Intro. Introduced in 1960s Quickly replaced barbiturates 12 are used in the US Page113 Treat insomnia, anxiety, seizures Addictive. Medical Uses. Remain the treatment of choice for anxiety disorders such as panic attacks or GAD

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Chapter 10- Benzodiazepines

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  1. Chapter 10- Benzodiazepines Anti-Anxiety

  2. Intro • Introduced in 1960s • Quickly replaced barbiturates • 12 are used in the US Page113 • Treat insomnia, anxiety, seizures • Addictive

  3. Medical Uses • Remain the treatment of choice for anxiety disorders such as panic attacks or GAD • Even though there are new Serotonin reuptake inhibitors- SSRI that are great for Anxiety physicans still use • Seizure d/o- Clonipin works well

  4. Pharmacology • Lipid soluble • Taken orally • Half-life of 1.7-100 hours • Duration of effect for as long as 280 hours after single dose • Inhances the effects of GABA-drug reduces the level of activity, lowering anxiety

  5. Side effects • Sedation • Drug induced hangovers • Visual motor disturbances MVA

  6. Addiction • Controversy over this • Some say not addictive, while other say this drug should not be used longer that 4 weeks due to abuse • W/D – seizures, shakes, tremors, irritabiltiy, vomiting, insomnia, death • Substance user more likely to abuse this drug, not to be administered to

  7. Withdrawal is difficult • Taper very slowly for as long as 8-12 weeks • Should use a mood stablizer such as Seroquel to help with the anxiety

  8. BuSpar • Newer drug as good at controlling anxiety • Rarely sedates • Does not control seizures • Great for treatment of anxiety where there is also depression • Marketed as non-addictive

  9. Ambien • New family of sleep inducing drug • Dose should not exceed 10 mg per day • Abuse potential low • Should not be used in people with addictive d/o, effects can trigger use

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