180 likes | 400 Views
Principles of Immunology Overview of Innate Immunity 1/19/06. “Education is not preparation for life. Education is life itself.” John Dewey. Review(T/F). Jenner was the first to introduce variolation Innate immune responses are specific T cells are either T-helper or T-cytotoxic cells
E N D
Principles of ImmunologyOverview of Innate Immunity1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey
Review(T/F) • Jenner was the first to introduce variolation • Innate immune responses are specific • T cells are either T-helper or T-cytotoxic cells • Immunological memory results in an amanestic response • All antigens are immunogens
Innate Immunity • Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components: • Anatomic • Physiologic • Phagocytic • Inflammatory
Word List • Antibody • Antigen • Complement • Endocytosis • Humoral • Macrophage • Monocyte • Neutrophil
Barriers to Antigenic Insult • Anatomic • Skin • Mucous membranes • Physiologic • Temperature • pH • Chemical mediators
Cellular and Inflammatory Components of Innate Immunity • Cellular • Phagocytic cells • Inflammatory • Vasodilation • Capillary permeability
Anatomic Barriers • Skin • Epidermis • Dermal layer • Sebaceous glands • Normal flora
Anatomic Barriers • Mucous membranes • Physical barrier • Secretions • Cilia • Normal flora
Physiologic Barriers • Temperature • Varies by species • Febrile response • Endogenous pyrogens • pH • Skin • GI tract
Physiologic Mediators of Innate Immunity • Chemical mediators • Enzymes • Interferon • Complement • Three pathways • Classical • MB Lectin • Alternative
Physiologic Mediators of Innate Immunity(cont’d) • Chemical mediators • Collectins • Toll-like receptors • Acute phase proteins
Cellular Component of Innate Immunity • Phagocytic cells • Monocytes • Neutrophils • Macrophages • Non-Phagocytic cells • Natural killer cells
Inflammatory Response • Hallmarks of inflammation • Rubor • Tumor • Calor • Dolor • Primary cell • Activated macrophage
Inflammatory Response(cont’d) • Biological effects • Vasodilation • Capillary permeability • Phagocyte migration
Inflammatory Response(cont’d) • Chemical mediators of inflammation • Histamine • Kinin system • Fibrin system