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Principles of Immunology Autoimmunity 4/25/06

Principles of Immunology Autoimmunity 4/25/06. Organs Specific Autoimmune Diseases. Hashimoto’s thyroiditis DTH like response to thyroid Ags Ab to thyroglobulin Hypothyroidism Pernicious anemia Ab to gastric parietal cells Interferes with vitamin update Reduced RBCs.

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Principles of Immunology Autoimmunity 4/25/06

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  1. Principles of ImmunologyAutoimmunity4/25/06

  2. Organs Specific Autoimmune Diseases • Hashimoto’s thyroiditis • DTH like response to thyroid Ags • Ab to thyroglobulin • Hypothyroidism • Pernicious anemia • Ab to gastric parietal cells • Interferes with vitamin update • Reduced RBCs

  3. Organs Specific Autoimmune Diseases • Goodpasture’s syndrome • Ab to Ag on basement membranes • C activation • Glomerulonephritis, pulmonary disease • Type 1 diabetes • Ab to beta cells of pancreas • DTF reaction • Cytokine induced damage

  4. Organs Specific Autoimmune Diseases • Myasthenia gravis • Ab to acetyl choline receptors • Blocks muscle activation • C activation and damage to muscle cells

  5. Systemic Autoimmune Disease • SLE • Ab to certain tissue antigens • Vasculitis • Diagnosis using anti nuclear antibodies • MS • Reaction to myelin sheath • Viral component?

  6. Systemic Autoimmune Disease • Rheumatoid arthritis • IgM which is anti IgG • Immune complexes • Chronic inflammation

  7. Genetics vs. Environment • HLA type • Sequestered antigens

  8. CD4 Cells and Autoimmune Disease • Transferable • Anti CD4 Ab protective

  9. Mechanisms • Release or expression of Ags • Cross reacting Ags

  10. Therapies • Cyclosporin • Interferes with T cell development • Anti-inflammatories

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