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Biophotonic Device for Dermatologic Disease Monitoring and Treatment

Development of a flexible light-emitting textile device for the monitoring and treatment of dermatologic diseases and carcinoma. This device aims to improve the efficiency, pain management, and cost-effectiveness of photodynamic therapy (PDT).

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Biophotonic Device for Dermatologic Disease Monitoring and Treatment

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  1. PHOS-ISTOSDevelopment of biophotonic device based on flexible light emitting textile dedicated to the monitoring and treatment for dermatologic diseases and carcinoma

  2. Context • Actinic Keratosis (AK) • Cutaneouscarcinoma in situ • Scaly erythematous plaque • Caused by sun damage • Epidemiology: • In Europe a prevalence of 15 % in men and 6 % in women has been documented • Over the age of 70 years, 34 % of males and 18 % of females were found to have AKs • Evolution • 10% risk to develop into invasive Squamous Cell Carcinoma Localization on sun-exposed areas

  3. Context • Photodynamic therapy (PDT) for Actinic Keratosis • Destruction of the AK cells by the interaction between three elements: • Photosensitizer: Protoporphyrin IX • Generated from a topical photosensitizing agent • Selectivelyaccumulated in the target cells • Light of appropriate wavelength • Oxygenin sufficient quantities in the target cells

  4. Context • Photodynamic therapy (PDT) for Actinic Keratosis • Benefits • Cure rates between 69 and 93 % • Excellent cosmetic results: no scare • Drawbacks • Important variation in cure rates  Perfectible • Very painful therapy • Half a day equipment occupancy per patient • Cost andlimited availability of equipment (onlyavailable in specialized environment)

  5. Objectives • Objective: To increase the efficiency of treatment • Solutions proposed by Phos-Istos: • To ensure illumination homogeneity using a flexible light emitting textile • To determine in real time the optimal treatment parametersby monitoring the PDT reaction • Flexible light emitting textile • proposed by Phos-Istos: Conventional rigid LED panels:

  6. Objectives • Objective: To manage patient pain • Solutions proposed by Phos-Istos: • To ensure oxygen in sufficient quantities using light fractionation (succession of illumination and rest periods) • To provide a cooling effect on the affected area Fractionated illumination proposed by Phos-Istos: Conventional continuous illumination: ON ON ON ON OFF OFF t Reoxygenation during rest periods t

  7. Objectives • Objective: To extend the use of PDT • Solutions proposed by Phos-Istos: • To miniaturize the system for ambulatory use • To limit the cost of the ambulatory system • Ambulatory system proposed by Phos-Istos: Conventional PDT systems:

  8. Evaluation • Comparative clinical evaluation of the light emitting textile for AK • Efficacy assessments: • Complete (or not) disappearance of lesions 3 months after treatment • Safety assessments • Pain assessment during treatment • Assessment of adverse effects (erythema, crusting…) 1-3 days after treatment. PDT using conventional red light-emitting diode light PDT using the light emitting textile

  9. 10 Partners • Institut National de la Santé et de la Recherche Médicale • REDEN • MODULIGHT • TEXINOV • KLINIKUM VEST GMBH • EREO • Centre Hospitalier Régional et Universitaire de Lille • FLUENCE THERAPEUTICS • Ecole Nationale Supérieure des Arts et Industries Textile (ENSAIT) • PROPLAST

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