Science for Global Health: Fostering International Collaboration

1. Science for Global Health: Fostering International Collaboration IANAS Science Funding Workshop 26-28 July 2009 Norka Ruiz Bravo,PhDSpecial Advisor to the DirectorNational Institutes of HealthU.S. Department of Health and Human Services

2. Outline • Global Burden of Disease • Biomedical Research Portfolio • NIH Structure, Function • Fogarty International Center

3. Communicable, Maternal, Perinatal, and Nutritional Conditions Non-Communicable Diseases Injuries Global Burden of Disease, Reported Mortality by Cause, 2004 Pop. ~ 6 billion Pop. ~ 874 million Source: World Health Report, 2008; Disease Control Priorities Project, 2006

4. Global Burden of Disease, Reported Mortality by Cause, Non-Communicable Diseases, Region of the Americas, 2004 Source: World Health Report, 2008; Disease Control Priorities Project, 2006

5. Clinical Research Clinical Research Translational Research Translational Research Basic Research Basic Research Private Sector - $60B NIH - $30 B Balanced National Biomedical Research Portfolio

6. NIH Extramural Grants (FY 2008) Supports > 150,000 PIs & Key Personnel About 83% of NIH budget Awards issued to > 3,000 institutions in > 100 countries Clinical, Basic, & Translational Research

7. National Institutes of Health, Bethesda, Maryland, Research Campus

8. National Institutes of Health: The Steward of Biomedical and Behavioral Research for the Nation MISSION Science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. METHODS • Supporting peer-reviewed scientific research at universities, medical schools, hospitals, and research institutions throughout United States and overseas • Conducting research in its own laboratories • Training research investigators • Developing and disseminating credible health information based on scientific discovery

9. Director Elias Zerhouni, M.D. Director, NIH National Institute National Institute National Institute National Institute National Institute National Institute National Institute National Institute National Institute of Arthritis and National Cancer of Child Health National Institute of Arthritis and National Cancer of Child Health of Allergy and on Alcohol Abuse of Allergy and on Alcohol Abuse on Aging Musculoskeletal Institute and Human on Aging Musculoskeletal Institute and Human Infectious Diseases and Alcoholism Infectious Diseases and Alcoholism and Skin Diseases Development and Skin Diseases Development National Institute on National Institute National Institute National Institute on National Institute National Institute National Institute National Institute Deafness and Other of Dental and of Diabetes and National Institute National Eye Deafness and Other of Dental and of Diabetes and National Institute National Eye of Environmental of Environmental Communication Craniofacial Digestive and on Drug Abuse Institute Communication Craniofacial Digestive and on Drug Abuse Institute Health Sciences Health Sciences Disorders Research Kidney Diseases Disorders Research Kidney Diseases National Institute National Institute National Institute National Heart, National Human National Institute National Heart, National Human National Institute of Neurological National Institute National Institute of Neurological National Institute of General Lung, and Blood Genome Research of General Lung, and Blood Genome Research of Mental Health Disorders and of Nursing Research of Mental Health Disorders and of Nursing Research Medical Sciences Institute Institute Medical Sciences Institute Institute Stroke Stroke National Center National Center National Institute of National Center on National Center Fogarty National Institute of National Center on National Center Fogarty for Complementary National Library for Complementary National Library Biomedical Imaging Minority Health and for Research Biomedical Imaging International Minority Health and for Research International and Alternative of Medicine and Alternative of Medicine and Bioengineering Health Disparities Resources Center and Bioengineering Health Disparities Resources Center Medicine Medicine Center for Center for Center for Center for Clinical Center Information Clinical Center Information Scientific Review Scientific Review Technology Technology = Institutes and Centers that award grants

10. NIH Budget Total FY 2009 Budget: $30.4 Billion 84% Outside NIH > 3,000 Organizations Worldwide 16% Inside NIH $2.9 B Intramural Research (10%) $1.2 B Staff & Buildings (4%) $0.6 B Other (2%)

11. NIH – Extramural and Other Grant Awards, by Type • Research Grant Programs • New Investigators Program • Multiple Principal Investigators • Research Supplement Programs • Ruth L. Kirschstein National Research Service Awards (NRSA) • Research Ethics and Training Grant Programs • NIH Career Development (K) Awards • Small Business Awards • Other Programs Source: http://grants2.nih.gov/grants/funding/funding_program.htm

12. Mission • Address global health challenges through innovative and collaborative research and training programs • Support and advance the NIH mission through international partnerships • “Science for Global Health” • FY 2009 Appropriation $68.7 million

13. Research and Research Training ~$50 million in grant awards • 1/3 Research, 2/3 Research Training • Awards range $10,000 - $1 million • Low and Middle Income Countries • Research Capacity Development and Sustainability

14. Extramural Research Grants – 8 Programs • Fogarty International Research Collaboration Award (FIRCA) • International Cooperative Biodiversity Groups (ICBG) • Ecology of Infectious Diseases (EID) • International Studies on Health and Economic Development (ISHED) • Int’l Tobacco and Health Research and Capacity Building Program • Global Research Initiative Program for New Foreign Investigators (GRIP) • Stigma and Global Health Research Program • Brain Disorders in the Developing World: Research Across the Lifespan

15. Extramural Training Grants – 14 Programs • Fogarty International Collaborative Traumaand Injury Research Training • International Clinical, Operational, and Health Services Research Training Awards for HIV/AIDS and Tuberculosis • International Maternal and Child Health Research Training • Fogarty International Clinical Scholars Research Training • Informatics Training for Global Health • International Collaborative Genetics Research Training • International Clinical, Operational, and Health Services Research Training Awards for Malaria • Global Infectious Diseases Research Training • International Research Ethics Education and Career Development • International Centers for Excellence in Clinical Research and Management Training • International Training Program inEnvironmental and Occupational Health • Global Research Training in Population Health • AIDS International Training and Research • Framework Programs for Global Health

16. International Clinical, Operational, and HealthServices Research Training Awards (ICOHRTA) Chronic Diseases: Goals and Objectives Bridge the training gap for clinical, operational and health services research in order to: • Strengthen capacity to conduct clinical, operational, and health services research to measure incidence and prevalence of non-communicable disorders and diseases; characterize disease burdens; and devise, evaluate and implement practical and affordable therapeutic or preventive interventions; • Help LMICs apply current knowledge and new discoveries to clinical and public health practice; and • Support programs at research institutions to both train researchersand to communicate and disseminate knowledge in support of evidence-based policies. • $2.5 million awarded to 12 institutions ($150k each in new awards and $200k each in competing renewals) under previous PA issued in FY 2006 • New Program Announcement anticipated • IC Partners: NCCAM, NIA, NIDA, NIDCR, NIMH, NINDS and OD/OD/Office of Dietary Supplements

17. Poland Ukraine Czech Republic Turkey China Bangladesh India Thailand Vietnam Brazil Peru Argentina ICOHRTA Chronic Diseases: Current Foreign Research and Training Sites

18. ICOHRTA Chronic: Current Research Training Areas • Evidence-based health care • Maternal & child health and nutrition • Suicide prevention and mental health • Nutrition-related chronic disease prevention • Finances and mental health • Smoking cessation and substance abuse • Oral health • Mental health, developmental disabilities and behavioral disorders • Community-based interventions to prevent drug use and HIV transmission Source: http://www.fic.nih.gov/programs/training_grants/icohrta/index.htm

21. Thank you for your attention!