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WP1 Progress report Vienna, 13 March 2011

WP1 Progress report Vienna, 13 March 2011. Achievements General. 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place Obtained approval from Medicines and Healthcare products Regulatory Agency

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WP1 Progress report Vienna, 13 March 2011

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  1. WP1 Progress reportVienna, 13 March 2011

  2. AchievementsGeneral • 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place • Obtained approval from Medicines and Healthcare products Regulatory Agency • Local Ethical Approval obtained provisionally, pending clarifications

  3. AchievementsStructural Imaging • Site survey ✔ • Site selection ✔ • Radiological and structural protocols (ADNI-GO) for 3T scanners finalised and Manual sent to sites ✔ • Image Management System (TrialTracker) and electronic data transfer tool (TrialWire) ✔ • Sites to upload protocol and return protocol form in progress • Sites to scan phantom and send details to IXICO in progress • Sites to scan 1 healthy volunteer and send details to IXICO not started Qualification and start scanning

  4. AchievementsStructural Imaging Innsbruck considering to join WP1

  5. AchievementsMagnetic Resonance Spectroscopy • London, Copenhagen, Utrecht have met and agreed protocol • Spectra (anterior cingulate and thalamus) from Copenhagen and Utrecht can be read and give reasonable values • The data can provide metabolite ratios • Currently exploring whether we can do correction for CSF in the MRS voxel which is a superior approach to the ratio method

  6. Milestones Deliverables • Qualification of sites, test of electronic data transfer tool • 2 Estimate of numbers (200 in total: if 10 sites, 20 patients per site) • Completion of preparation work for MRI sites • Start scanning

  7. Possible concerns Combination of MRS data: - Existing power calculation did not take into account the greater variability of multicentre design - Increase number of subjects with MRS at each site (~30-40 each: existing plan is for 20 subjects scanned twice in London and Copenhagen, so it would be slightly more than double) - If datasets cannot be combined, we could explore whether findings are reproduced across sites

  8. Planned progress • Obtain final approval from local ethics • Qualify sites • Start recruitment and scanning • All sites to continue to scan phantom regularly plus 2 healthy volunteers (from the site) yearly, preferably every 6 months and before and after upgrades

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