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U41: Research resource for Image guided therapy

U41: Research resource for Image guided therapy. PI: Ferenc Jolesz. U41 Image guided therapy. Background & Significance IGT technology growth Clinical imaging growth Aim Advance and propagate novel image guided procedures

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U41: Research resource for Image guided therapy

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  1. U41: Research resource for Image guided therapy PI: Ferenc Jolesz

  2. U41 Image guided therapy • Background & Significance • IGT technology growth • Clinical imaging growth • Aim • Advance and propagate novel image guided procedures • To dev and implement IGT technologies and allow rapid deployment in clinic

  3. U41 program outline • Technology Research & Development cores • Admin core • Biostatistics & Validation core • Collaborations • Internal (11) • External (8)

  4. Program outline • 5 TRD cores • Computational • Leader: Ron Kikinis • Imaging • Leader: Larry Panych • MRI-guided therapy • Leader: Clare Tempany • Image guided Brain tumor surgery • Leader: Alex Golby • Focused Ultrasound • Leader:Kullervo Hynynen

  5. Training & Dissemination • Leaders: John Carrino & Nancy Drinan • Continuous activities on site • First Monday seminars • R25 training grant • Visiting fellowships • Post docs, doctoral students • Graduate and undergraduate students

  6. Collaborations • Technology based • Advancing imaging and image processing into the OR of the future • AMIGO • Testing utility of IG • Interventional Radiology • Surgery • Cancer therapy • Cardiology (FUS ablation)

  7. U41 Collaborative projects • Internal (11) NIH funded grants • d2.1 G CT R01 AG 19513 MR guided prostate diagnosis and brachytherapy • External (8) NIH grants with BWH collaborators • d2.1p Christos Davatzikos 1R01 CA 104976 Targeted prostate biopsy using mathematical optimization

  8. External collaborations Major groups • GE • Doumoulin/Pelc • 3 projects stem from the Engineering research center for computed surgical systems and technology (CISST ERC)of Johns Hopkins • Targeted biopsy (Christos Davatzikos) • Transrectal prostate therapy robot in closed MRI scanner (Gabor Fichtinger)

  9. MRI guided therapy core • Neurosurgery • Prostate program • Interventional radiology • Tumor ablation program (SGS0 • Spine interventions (JC)

  10. TRD core and collaborative interactions:An example • Prostate intervention • Paradigm shift • Improved image quality • Higher field strength magnets • Magnet design issues • Closed bore systems • MRT core • Internal collaboration • External collaboration

  11. Overlaid Choline/Citrate image Prostate Image guided diagnosis & therapy Detection Staging Brachytherapy FEM Based Deformation Prostate biopsy Mutual Information MR Robotics Treatment monitoring SPL Infrastructure High Performance Computing Gigabit network Terabyte storage

  12. Optimized biopsy project right left Probability of cancer occurrence shown in green (left) and its adaptation (middle) to a stack of segmented intra-operative MR images obtained at the BWH (right). Optimal biopsy sites are transferred to the patient's space. * NIH R01 PI: Davatzikos et al

  13. Validation methods • Pre-clinical • IGT technology-imaging system , guidance and monitoring techniques-organ/disease specific • IGT Procedural • Image registration & segmentation • DICE-Statistical analysis of registration matching • Staple-analysis of expert and automated methods • Procedure Feasibility • Safe and effective • Treatment specific -Cancer specific goals • Patient safety, toxicity profiles, Cancer control-long and short term outcomes

  14. 3T endorectal coil MRI Bob Lenkinsky & Neil Rofsky BIDMC

  15. Open vs Closed bore magnet design

  16. 1.Tempany CMC, McNeil BJ. Advances in biomedical imaging. JAMA 2000; 285(5):562-567.

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