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Edema. Zhao Mingyao.ZZU. Nuo Ya square boat. Dayu. 1.Concept. A large amount of body fluid accumulates in the interstitial space (interstitial fluid↑). fluid. blood vessel. Cell. interstitial space. 60% of body weight). Edema.
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Edema Zhao Mingyao.ZZU
Nuo Ya square boat Dayu
1.Concept A large amount of body fluid accumulates in the interstitial space (interstitial fluid↑) fluid blood vessel Cell interstitial space 60% of body weight)
Edema Soft tissue swelling due to expansion of the interstitial volume A large amount of body fluid accumulates in the interstitial space (interstitial fluid↑)
Distinguish concepts • Edema • Hydrops • Cellular edema
Edema Cause, site, type, formation, feature, impact, treatment
Does the body weight certainly increase in all type of edema?
2.Pathogenesis (1)Disturbance of Transcapillary Fluid Exchange (2)Sodium and Water Retention
Formation of interstitial fluid review back-flow
(1)Disturbance of Transcapillary Fluid Exchange Formation > back-flow(for interstitial fluid ) 1. Capillary blood pressure↑ 2. Plasma colloid osmotic pressure↓ 3. Capillary wall permeability↑ 4. Obstruction of lymphatic flow
↑Capillary Hydrostatic Pressure Filariasis
(2) Sodium and Water Retention ①GFR↓ ②Reabsorption↑ of renal tubule Reabsorption of salt
afferent arteriole proximal tubule Renal glomerulu Bowman's space efferent arteriole ①Glomerular filtration rate (GFR) ↓ Primary ↓: renal failure Second ↓: ECBV ↓
②Reabsorption↑of Na+ and H2O ⅰ. ADS ↑& ADH ↑ ⅱ. ANF、kinin、PGE↓ ⅲ. Redistribution of renal blood flow ⅳ. Filtration fraction↑ Atrial natriuretic factor
Redistribution of renal blood flow Cortical nephrons proximal medullary nephrons Collecting tubules
Reabsorption ↑ sympathetic nerve excitation ↑
afferent arteriole proximal tubule Renal glomerulu Bowman's space efferent arteriole Filtration fraction↑ FF = GFR/ renal plasma flow efferent arteriole contraction > afferent arteriole contraction
3. Treatment of edema neither begin nor end with the administration of diuretics. ① First, treat the underlying disease ②Decrease Na+ intake, either dietary or intravenous ③Increase excretion of sodium and water a. Diuretics - remember, these are palliative, not curative. b. Bed rest, local pressure
Question • Why , sometimes, can`t we get satisfied effects when treat some systemic edema (anasarca)with diuretics, but use albumin to get well result?