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Metabolic Syndrome By: Dr.AP.Ahmed el-Shaer Dr.Mohamed El-Zayat

Metabolic Syndrome By: Dr.AP.Ahmed el-Shaer Dr.Mohamed El-Zayat. Definition :. Pathophysiology of Metabolic Syndrome. 1-Central (Visceral) Obesity. 2-Insulin Resistance. 3- Atherogenic Dyslipidemia. 4- Hypertension. 5- Thrombogenicity.

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Metabolic Syndrome By: Dr.AP.Ahmed el-Shaer Dr.Mohamed El-Zayat

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  1. Metabolic Syndrome By: Dr.AP.Ahmed el-Shaer Dr.Mohamed El-Zayat

  2. Definition:

  3. Pathophysiology of Metabolic Syndrome 1-Central (Visceral) Obesity 2-Insulin Resistance 3-Atherogenic Dyslipidemia 4-Hypertension 5-Thrombogenicity 6-Inflammation and Endothelial Dysfunction

  4. Systemic Effects of Metabolic Syndrome Diabetes Acute stroke in the elderly. kidney Liver Pregnancy Surgical patient

  5. Insulin Resistance

  6. Strategies for Metabolic Management • Insulin Resistance and Hyperglycemia: • A) Insulin secretagogues • Sulfonylureas • Nonsulfonylureas (repaglinide and nateglinide) • B)Insulin-sensitizing agents • Biguanides (metformin) • PPAR- ligands (thiazolidinediones) • Atherogenic Dyslipidemia: • HMG-CoA reductase inhibitors (statins) • PPAR- ligands (fibrates) • Increased Blood Pressure: • Inhibitors of the renin–angiotensin system • B-Blockers • Calcium channel antagonists

  7. Exercise and Mobilization Nutrition

  8. Anesthesia and Analgesia Volatile anesthetics Intravenous induction agents Opioids Neuraxial blockade

  9. Thank you

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