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THE REPRODUCTIVE SYSTEM . D. C. Mikulecky Faculty Mentoring Program Virginia Commonwealth University. ANATOMY OF THE MALE REPRODUCTIVE SYSTEM. TESTIS SCROTUM PENIS SEMINAL VESSICLES, PROSTATE GLAND, BULBOURETHRAL GLANDS EPIDIDYMUS, VAS DEFERENS, URETHRA. TESTES.
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THE REPRODUCTIVE SYSTEM D. C. Mikulecky Faculty Mentoring Program Virginia Commonwealth University
ANATOMY OF THE MALE REPRODUCTIVE SYSTEM • TESTIS • SCROTUM • PENIS • SEMINAL VESSICLES, PROSTATE GLAND, BULBOURETHRAL GLANDS • EPIDIDYMUS, VAS DEFERENS, URETHRA
TESTES • PRIMARY REPRODUCTIVE ORGANS OR GONADS • PRODUCTION OF SPERM • SUSPENDED OUTSIDE THE BODY CAVITY BY SCROTUM
PENIS • DEPOSITS SPERM IN FEMALE • ERECTILE TISSSUE (VASCULAR) • ERECTION RESULTS FROM GORGING TISSUE WITH BLOOD • ERECTION IS A PARASYMPATHETIC SPINAL REFLEX TO TACTILE AND OTHER STIMULATION ENHANCED BY SYMPATHETIC INHIBITION
SEMINAL VESSICLES, PROSTATE GLAND, BULBOURETHRAL GLANDS • PROVIDE THE BULK OF THE SEMEN, A MIXTURE OF SECRETIONS, SPERM AND MUCOUS • FRUCTOSE AND PROSTAGLANDINS FROM SEMINAL VESSICLES • ALKALINITY AND CLOTTING ENZYMES FROM PROSTATE • LUBRICANT FOR INTERCOURSE FROM BULBOURETHRAL GLANDS
EPIDIDYMUS, VAS DEFERENS, URETHRA: EJACULATION • ROUTE OF EXIT OF SPERM • DUCTUS DEFERNS STORES SPERM • DURING EMMISSION PHASE OF EJACULATION SPERM ARE EMPTIED INTO URETHRA BY SYMPATHETICALLY INDUCED CONTRACTIONS • MOTOR NEURON INDUCED CONTRACTIONS OF SKELETAL MUSCLES AT BASE OF PENIS EXPELL THE SEMEN DURING EXPULSION PHASE OF EJACULATION • EJACULATION IS A PART OF ORGASM
ANATOMY OF THE FEMALE REPRODUCTIVE SYSTEM • VAGINA • UTERUS • CERVIX • CLITORIS • LABIA • OVARIES • OVIDUCTS
VAGINA • ENTRANCE TO UTERUS • PLACE WHERE PENIS INSERTS TO DEPOSIT SPERM • MUSCULAR, EXPANSIBLE TUBE
UTERUS • MAINTAINS FETUS DURING PREGNANCY • MUSCULATURE CONTRACTS TO EXPEL FETUS AT BIRTH
CERVIX • LOWEST PORTION OF THE UTERUS • PROJECTS INTO VAGINA • CERVICAL CANAL SERVES AS PATHWAY FOR SPERM DURING SEXUAL INTERCOURSE • PASSAGWAY FOR DELIVERY OF BABY FROM UTERUS
CLITORIS • ERECTILE TISSUE ANALOGOUS TO PENIS IN MALE • SENSITIVE AND EROTIC • AT FOLD OF LABIA MINORA
LABIA • SKIN FOLDS • MAJORA- OUTER • MINORA-INNER • AROUND VAGINAL AND URETHRAL OPENINGS
OVARIES • FEMALE GONADS • IN ABDOMEN • PRODUCE OVA • SECRETE ESTROGEN AND PROGESTERONE
OVIDUCTS • LINK OVARIES TO UTERUS • FALOPIAN OR UTERINE TUBES • PICK UP OVA AT OVULATION • SITE FOR FERTILIZATION
SEXUAL INTERCOURSE • COITUS OR COPULATION • AT SOME POINT PENIS IS INSERTED INTO VAGINA • SEXUAL RESPONSE CYCLE
THE FOUR PHASES OF SEXUAL CYCLE • EXCITEMENT • PLATEAU • ORGASM • RESOLUTION
EXCITEMENT • CAN BE INITIATED PHYSICALLY (TACTILE STIMULI)AND/OR PSYCHOLOGICALLY • CLITORIS, SURROUNDING PERINEAL AREA AND PENIS ARE PRIMARY AREAS FOR THIS • OTHER SENSITIVE AREAS MAY CONTRIBUTE IF STIMULATED, BREASTS, TESTICLES, ETC. • ERECTION OF PENIS AND CLITORIS RESULT (CLITORIS IS A HOMOLOGUE OF THE PENIS) • LUBRICATION FROM VAGINAL CAPILLARIES, GLANDS AT OPENING OF VAGINA AND PENIS PREPARE FOR INTERCOURSE
PLATEAU • INTENSIFICATION OF CHANGES DURING EXCITEMENT PHASE • HEART RATE AND BREATHING CHANGES • MUSCLE TENSION INCREASES • VAGINA TIGHTENS AROUND PENIS HEIGHTENING SENSATION • UTERUS RAISES UPWARD CREATING SPACE FOR EJACULATE
MALE ORGASM • RHYTHMIC CONTRACTIONS DURING SEMEN EXPULSION • INVOLUNTARY RHYTHMIC THROBBING OF PELVIC MUSCLES • BREATHING AND HEART RATE INCREASED • EMOTIONAL RESPONSE: RELEASE AND COMPLETE GRATIFICATION • RESOLUTION PHASE INVOLVES SYMPATHETIC VASOCONSTRICTION • A REFRACTORY PERIOD PREVENTS MULTIPLE ORGASMS IN THE MALE
EPIDIDYMUS, VAS DEFERENS, URETHRA: EJACULATION • ROUTE OF EXIT OF SPERM • DUCTUS DEFERNS STORES SPERM • DURING EMMISSION PHASE OF EJACULATION SPERM ARE EMPTIED INTO URETHRA BY SYMPATHETICALLY INDUCED CONTRACTIONS • MOTOR NEURON INDUCED CONTRACTIONS OF SKELETAL MUSCLES AT BASE OF PENIS EXPELL THE SEMEN DURING EXPULSION PHASE OF EJACULATION • EJACULATION IS A PART OF ORGASM
FEMALE ORGASM • PARALLELS THAT IN MALES WITH TWO EXCEPTIONS • NO COUNTERPART TO EJACULATION • NO REFRACTORY PERIOD-MULTIPLE ORGASMS POSSIBLE
SEX DETERMINATION AND DIFFERENTIATION • SEX CHROMOSOMES X AND Y • 22 PAIRS AUTOSOMAL • 1 PAIR DETERMINES SEX: XX OR XY • FEMALE REPRODUCTIVE TRACT AND EXTERNAL GENETALIA DEVELOP REGARDLESS • TESTOSTERONE PRODUCES MALE CHARACTERISTICS • EVIDENT AFTER 10 TO 12 WEEKS
MALE REPRODUCTIVE PHYSIOLOGY • DEPENDS ON TESTOSTERONE • TESTICULAR LEYDIG CELLS SECRETE TESTOSTERONE • TESTES DESCEND AND PASS OUT OF ABDOMINAL CAVITY
TESTOSTERONE: BEFORE BIRTH • BEFORE BIRTH:MASCULINIZES REPRODUCTIVE TRACT AND EXTERNAL GENETALIA • DESCENT OF TESTES • CEASES AT BIRTH • RETURNS AT PUBERTY
PUBERTY IN THE MALE • USUALLY 10-14 YEARS OLD • ENDOCRINE,PHYSICAL, AND BEHAVIORAL • LEYDIG CELLS “AWAKE”
TESTOSTERONE: AT PUBERTY • SPERMATOGENESIS • ACCESSORY SEX GLANDS ENLARGE AND BECOME SECRETORY • PENIS AND SCROTUM ENLARGE • LIBIDO
EFFECTS OF TESTOSTERONE ON SECONDARY SEX CHARACTERISTICS • HAIR GROWTH PATTERN • DEEP VOICE • THICK SKIN • MALE BODY CONFIGURATION
OTHER EFFECTS OF TESTOSTERONE • BONE GROWTH • PROTEIN ANABOLIC EFFECT • EVENTUALLY STOPS BONE GROWTH • AGGRESSIVE BEHAVIOR(IN ANIMALS) • MALE MENOPAUSE
CONTROL OF TESTICULAR FUNCTION HYPOTHALAMUS GRH + ANTERIOR PITUITARY FSH LH TESTES SERTOLI CELL LEYDIG CELL SPERMATOGENESIS TESTOSTERONE INHIBIN
FEMALE REPRODUCTIVE PHYSIOLOGY • CYCLIC • OOGENESIS • FERTILIZATION • PREGNANCY • DELIVERY • MENOPAUSE
THE OVARIAN CYCLE • FOLLICULAR PHASE • LEUTEAL PHASE • ONLY INTERRUPTED BY PREGNANCY • ENDS AT MENOPAUSE
FOLLICULAR PHASE • PRIMARY OOCYTE IS IN A PREPARATORY PHASE • FIRST MEIOTIC DIVISION • OVULATION • ESTROGEN SECRETED FROM FOLLICLE
LEUTEAL PHASE • AFTER OVULATION • DEVELOPMENT OF CORPUS LUTEUM • SECRETES PROGESTERONE AND ESTROGEN • DEGENERATES AFTER 2 WEEKS IF NOT FERTILIZED
IF NOT FERTILIZED • CORPUS LEUTEUM DEGENERATES • ESTROGEN AND PROGESTERONE LEVELS FALL • MENSTRUAL PHASE INVOLVES SLOUGHING OF PREPARED ENDOMETRIUM • NEW CYCLE STARTS-NEW FOLLICLES DEVELOP AND BEGIN SECRETING ESTROGEN
CONTROL OF FSH AND LH SECRETION DURING FOLLICULAR PHASE HYPOTHALAMUS GRH + ANTERIOR PITUITARY FSH LH OVARY LOW LEVELS OF ESTROGEN INHIBIN
CONTROL OF LH SURGE AT OVULATION HYPOTHALAMUS GNRH + ANTERIOR PITUITARY FSH LH OVARY MATURE FOLLICLE HIGH LEVELS OF ESTROGEN OVULATION
FEEDBACK CONTROL DURING LUTEAL PHASE HYPOTHALAMUS GNRH + ANTERIOR PITUITARY LH OVARY CORPUS LUTEUM HIGH LEVELS OF PROGESTERONE MODERATE LEVELS OF ESTROGEN
FERTILIZATION • IN OVIDUCT • SPERM DEPOSITED IN VAGINA AT EJACULATION • TRAVEL TO OVIDUCT TAKES A LITTLE OVER 1/2 HOUR • CERVICAL CANAL IS OPEN DUE TO ESTROGEN BEING HIGH AND REMAINS OPEN TWO TO THREE DAYS • SPERM ENTER UTERUS AND ARE CHURNED AROUND • WHEN REACH OVIDUCT, SMOOTH MUSCLE CONTRACTIONS PROPELL THEM ONWARD • MATURE EGG RELEASES A CHEMOTACTIC AGENT • OUT OF SEVERAL HUNDRED MILLION ONLY A FEW THOUSAND MAKE IT • TAIL OF SPERM MANEUVERS IT FOR FINAL PENETRATION
HORMONES OF PREGNANCY • PLACENTA IS ORGAN OF EXCHANGE • PLACENTA SECRETES HUMAN CHORIONIC GONADOTROPIN (HCG)-PROLONGS LIFE OF CORPUS LUTEUM • ESTROGEN AND PROGESTERONE LEVELS EVEN HIGHER NOW • AFTER 10 WEEKS PLACENTA TAKES OVER
PARTURITION • POSITIVE FEEDBACK • CERVICAL DILATION • DELIVERY • DELIVERY OF PLACENTA
LACTATION • MAMMARY GLANDS OR BREASTS • MILK PRODUCING GLANDS AND FAT • ACTION OF ESTROGEN AND PROGESTERONE IS TO PREPARE GLANDS DURING PREGNANCY • ALSO BLOCK PROLACTIN’S STIMULATION • OXYTOCIN-MILK EJECTION • SUCKLING TRIGGERS OXYTOCIN RELEASE