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Fig. 13.1 (a) Schematic diagram of the TRPML3 channel showing the six-transmembrane topology, cytosolic amino-(NH2) and carboxy-(COOH) termini, and the location of the isoleucine to threonine (I362T) and alanine to proline (A419P) mutations (red dots). (b) Confocal image showing immuno labeling of TRPML3 at the base of the stereociliary hair bundle of inner (arrow) and outer hair cells (arrowhead). (c, d) Confocal images of stereocilia of wildtype (c) and VaJ/VaJ(d) inner (I) and outer (O1-3) hair cells. (e) Schematic diagram of the voltage/current relationship of wildtype and mutant (A419P) TRPML3 Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: 978-94-007-0264-6, Springer
Fig. 13.2 Schematic diagram of suggested function of TRPML3 in acidification and differentiation of endosomes [21] Transient Receptor Potential Channels, Md. Shahidul Islam (Ed.) ISBN: 978-94-007-0264-6, Springer
