Principles

1. Principles • Open eyes and ears for opportunities • Know national, state and local health priorities • Think about your observations • Go to national meetings and build bridges • Look at every grant opportunities • Collaborate, collaborate, collaborate • Who is local? Who is regional? Are their other institutions and individuals in the area who might strengthen what you want to do? • Swallow your pride • Diverse funding sources • The bigger the pot the greater the competition • Local resources are often “sweeter” • If you do not write, you will not get

2. National Priorities Obesity Diabetes Asthma Childhood Cancer Accidents/Trauma Access/Disparities Local Problems Obesity Diabetes Asthma Childhood Cancer Accidents/Trauma Access/Disparities A PERFECT MATCH Know national, state and local health priorities

3. Land of Opportunity The population of this region is ~ 6.5 million people, with ~1.8 million children <18 years of age (~25% of the children in Texas). The region includes 3 of the 10 fastest growing metropolitan areas in the US (Austin, McAllen, and Laredo are #4, #5 and #9, respectively). Texas has the second youngest population and the highest number of children per family in the US.

4. Principal Investigator: Daniel E. Hale, MD Investigators: Jane Lynch, MD, Nancy Amodei, PhD Staff: Rose Ann Barajas, Guadalupe Rupert, Elisa Morales, Aimee Wauters, Jeannette Perez Partners: Children’s Center at the TDI Funding: NIH (1 of 14 in US) Goal: Prospective randomized control trial of the optimal way(s) to manage Type 2 diabetes in youth Number: 50-60 children in SA 750 children nationally TODAYTreatment Options for Diabetes Type 2 in Adolescents and Youth Think about your observations

5. Principal Investigator: Roberto Trevino, M.D. Investigators: Art Hernandez and Zenong Yin (UTSA) Tinker Murray (TSU), Connie Mobley (UNLV) Coordinator: Irene Hernandez Partners: San Antonio ISD (Roger Rodriquez) Social & Health Res. Ctr. Funding: NIH (one of 7 US sites) Goal: A school-based diabetes primary prevention program for middle school children Number: 3 control and 3 intervention schools/site ~700 children locally ~5,000 children nationally HEALTHY Collaborate, collaborate, collaborate & Swallow your pride

6. Principal Investigator: Roberto Trevino, MD Coordinator: Miguel Berry Partners: Laredo ISD and United ISD Laredo Health Department Office of S.Texas Programs UTSA, SHRC Funding: NIH Goal: Translational trial where the interventions designed to reduce the risk of DM2 is done by the school, assessments are done by Health Department. Number: 16 control and 16 intervention schools (~6000 4th grade children) Proyecto Bienestar Laredo Look at every grant opportunity

7. SAFARISan Antonio Family Assessment of Risk In Youth PrincipaI Investigator: Ravi Duggirala, PhD. Co-Investigators: Ralph DeFronzo, MD, Michael Stern, MD Coordinator Sharon Fowler, PhD Partners: Southwest Foundation for Biomedical Research Funding: NIH (NIDDK) Start: March 2005 Duration: 4 years Goal: Delineate the early markers of the metabolic syndrome in the progeny of the SAFH and SAFD cohort Number: 750 children Collaborate, Collaborate, Collaborate

8. Principal Investigator: Daniel E. Hale, M.D. Coordinator: Ivette Torres Partner: UTHSCSA RAHC Funding: HRSA & Harlingen Economic Development Commission Goal: Establish the first nutrition center in the US dedicated to Hispanic issues Have funded 10 pilot projects to date Will be funding an additional 2 pilot projects in Harlingen for each of the next 3 years United States Hispanic Nutrition Research and Education Center (Harlingen) Local resources are often sweeter

9. Principal Investigator: Daniel E. Hale, M.D. Coinvestigator: Michael Rogers, MD Coordinator: Miranda Muzina, MD Partners: Harlandale ISD (Rio Grande City ISD) Funding: Baptist Health Foundation (HRSA – OAT) Goal: To compare the effects of a telemedicine based behavioral weight control program with a locally delivered weight control program Number: 3000 Phase 1 (screening) 120 Phase 2 (intervention) DiRReCTDiabetes Risk Reduction via Community-based Telehealth Open eyes and ears for opportunities

10. PrincipaI Investigator: Daniel E. Hale, MD CoInvestigators: Multiple Coordinator: Rose Irene Garza, RN (Robin Tragus, RN, CDE) Partners: Children’s Center at the TDI Funding: Pharmaceutical Companies Goal: Infrastructure to permit a wide range of pharmaceutical trials Current: Growth registries, GH, IGF1 and Byetta clinical trials Pediatric Pharmaceutical Trials Go to national meetings and build bridges

11. PrincipaI Investigator: Daniel E. Hale, MD Co-Investigators: Jane Lynch, MD, Michael Rogers, MD Coordinator: Rose Irene Garza, RN Craig Zahn Partners: Children’s Center at the TDI Funding: NIH Goal: Understand the natural history of DM1 Develop prevention trials for DM1 TrialNet The bigger the pot, the greater the competition

12. PrincipaI Investigator: Daniel E. Hale, MD Co-Investigators Donald J. Dudley, MD, Victor German, MD, PhD, Claudia Miller, MD, Nhung Tran MD, Louise O’Donnell, PhD, Pamela Wood, MD, Brad Pollock, PhD, Helen Hazuda, PhD Coordinator: Karen Aufdemorte Partners: University Health System Christus Santa Rosa Health Department Methodist, Baptist, Nix Funding: NIH Goal: Longitudinal study of the impact of the environment on child health and disease National Children’s Study Swallow your pride & If you do not write, you will not get