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The TUNL task: A measure of working memory and pattern separation. Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab The University of Cambridge. Delayed Non-Matching to Position (DNMTP). Widely used measure of spatial working memory ( Dunnett 1985).
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The TUNL task: A measure of working memory and pattern separation Katie McAllister PhD Candidate Bussey-Saksida Cognitive Systems Neuroscience Lab The University of Cambridge
Delayed Non-Matching to Position (DNMTP) Widely used measure of spatial working memory (Dunnett 1985)
Rats cheat! Chudasama & Muir (1997)
Trial-Unique Non-Matching to Location (TUNL) Sample Phase Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory
Trial-Unique Non-Matching to Location (TUNL) Choice Phase
Mediating Behaviours Not Observed Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory
Hippocampal lesions cause delay- and separation-dependent impairments in TUNL Large Small Large Small Talpos, McTighe, Dias, Bussey & Saksida (2010) Neurobiology of Learning and Memory
PFC lesions cause delay-dependent impairments in TUNL * No delay 6 second delay McAllister, Saksida, Bussey, Unpublished data
PFC lesions do not cause separation-dependent impairments in TUNL Large separation Smaller separation McAllister, Saksida, Bussey, Unpublished data
PFC lesions do not cause separation-dependent impairments in TUNL Very small separation Adjacent McAllister, Saksida, Bussey, Unpublished data
The TUNL Task • Trial-unique method prevents mediating behaviours • Allows assessment of working memory, pattern separation, and the effects of interference • A part of the standardized task battery
Thank You! Dr. Tim Bussey Dr. Lisa Saksida CSN Lab Members Funding was generously provided by Takeda Cambridge Ltd and the Cambridge Commonwealth Trusts.