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Molecular Evolution of West Nile Virus

Molecular Evolution of West Nile Virus. A Big Problem !. Family: Flaviviridae Origin: West Nile district of Uganda in 1937 Mode of Transmissions: Mainly by mosquitoes Related to Dengue Fever, Yellow Fever, & St. Louis Encephalitis Genome = 11,009 bp. Single Stranded RNA genome

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Molecular Evolution of West Nile Virus

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  1. Molecular Evolution of West Nile Virus A Big Problem !

  2. Family: Flaviviridae Origin: West Nile district of Uganda in 1937 Mode of Transmissions: Mainly by mosquitoes Related to Dengue Fever, Yellow Fever, & St. Louis Encephalitis Genome = 11,009 bp

  3. Single Stranded RNA genome Enveloped & Spherical Diameter 40-50 nm

  4. West Nile Virus in the United States as of March 10, 2004

  5. gi_9930133_gb_AF260967.1_AF2 ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI Flamingo_382_AF196835.2_AF19 ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI Crow_265_gb_AF404753.1__West ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI Grouse[3282]_gb_AF404755.1__ ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI Crow_3356_gb_AF404756.1__Wes ASTGLFNPMILAAGLITCDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI Horse_gb_AF404757.1__West_Ni ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI ****************:********************************* gi_9930133_gb_AF260967.1_AF2 DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD Flamingo_382_AF196835.2_AF19 DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD Crow_265_gb_AF404753.1__West DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD Grouse[3282]_gb_AF404755.1__ DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD Crow_3356_gb_AF404756.1__Wes DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD Horse_gb_AF404757.1__West_Ni DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD ************************************************** gi_9930133_gb_AF260967.1_AF2 VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL Flamingo_382_AF196835.2_AF19 VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL Crow_265_gb_AF404753.1__West VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL Grouse[3282]_gb_AF404755.1__ VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL Crow_3356_gb_AF404756.1__Wes VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL Horse_gb_AF404757.1__West_Ni VRLDDDGNFQLMNDPGAPWKIWMLRMACLAISAYTPWAILPSVIGFWITL **************************.****************:******

  6. ASTGLFNPMILAAGLIACDPNRKRGWPATEVMTAVGLMFAIVGGLAELDI DSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVD VRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITL

  7. Conclusions: West Nile Virus may evolve rapidly Especially the genes coding the structural envelope

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