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Enantioselective Total Synthesis of ( - )-Napyradiomycin A1 via

Enantioselective Total Synthesis of ( - )-Napyradiomycin A1 via Asymmetric Chlorination of an Isolated Olefin. Scott A. Snyder, Columbia Uni V ersity. J. AM. CHEM. SOC . 2009, 131 , 5744–5745. ℃. ℃. Tandem Knoevenagel–electrocyclic reaction:.

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Enantioselective Total Synthesis of ( - )-Napyradiomycin A1 via

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  1. Enantioselective Total Synthesis of (-)-Napyradiomycin A1 via Asymmetric Chlorination of an Isolated Olefin Scott A. Snyder, Columbia UniVersity. J. AM. CHEM. SOC. 2009, 131, 5744–5745

  2. ℃ ℃

  3. Tandem Knoevenagel–electrocyclic reaction:

  4. Chiral Lewis Acid for the Asymmetric Induction of Some Diels-Alder Reactions:

  5. Supporting Information: there was no erosion in this step. At larger scales, up to 5-8% e.e. decrease could be observed; in these cases, we believe that a mechanism other than replacement is involved in order to erode chirality. This hypothesis is the subject of current investigations.

  6. Synlett. 1995, 1261.

  7. Johnson-Claisen rearrangement:

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