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Frances M Cowan

Estimation of the HIV care cascade for female sex workers in Zimbabwe: Baseline results of the SAPPH-IRe Trial. Frances M Cowan. Collaborative project. Zimbabwe Ministry of Health and Child Care and Centre for Sexual Health and HIV AIDS Research, Zimbabwe,

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Frances M Cowan

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  1. Estimation of the HIV care cascade for female sex workers in Zimbabwe: Baseline results of the SAPPH-IRe Trial Frances M Cowan

  2. Collaborative project Zimbabwe Ministry of Health and Child Care and Centre for Sexual Health and HIV AIDS Research, Zimbabwe, in collaboration with UNFPA, PSI Zimbabwe, the National AIDS Council, University College London, the London School of Hygiene and Tropical Medicine, and RTI International.

  3. ‘Sisters with a Voice’ Established in 2009 with five sites- expanded in 2013 to 36 sites nationally Developed in close consultation with SWs and other stakeholders • Clinical services • Supported by 130 peer educators (50% paralegals) • Community mobilisation • >17,800 SW seen

  4. ‘Sisters’ services • Health education • Safer sex counseling • Free male and female condoms • HIV testing and counseling • Referral to treatment and care for HIV positive women • Syndromic management of STIs • Contraception

  5. Overview of trial design

  6. Conduct baseline survey using RDS in 14 outreach sites Recruit ≈ 200 SWs per site (total n=2,800 ) Random allocation of 7 matched sites to intervention arms Process Evaluation Program data collection • SAPPH-IRe Ix Sites • Usual care plus: • HIV negatives • Repeat HTC, Offer of PrEP • HIV positives • PoC CD4; On site ART • Intensified community mobilisation with SMS adherence support • Adherence sisters program Usual Care Sites Health education, HTC Referral to government HIV care services as needed, Syndromic STI Contraception, Condoms Cervical Ca screening, Legal advice After 18 months conduct endline survey using RDS in all 14 sites. Recruit ≈ 200 SWs per site (total n=2,800 )

  7. Secondary Outcomes Primary Outcome Proportion of all SW who are infectious with HIV (viral load >1000 copies/ml). % HIV-infected SW who are infectious % on taking ART who have viral load >1000 who have drug resistance Self-reported QoL, psychological health and functioning % adherent to ART for treatment % SWs always using condoms with clients in last month % of SWs who know HIV status Perceived levels of peer support % engaged in prevention/care) appropriate to their individual place on the care continuum

  8. Respondent Driven Sampling Survey Rapid mapping at each site Seed selection • 8 at 4 sites, 6 at 10 sites RDS Survey • Interviewer-administered on tablets • DBS for HIV Ab testing and Viral Load Analysis • Weighted prevalence estimates accounting for RDS for whole populations and sub-populations • Random effects regression to explore associations

  9. Baseline RDS survey results

  10. Enrolment • Survey conducted Nov 13 2013 to 20 Dec 2013 • Aimed to recruit 200 women each site

  11. Age at survey • * percents are RDS weighted

  12. Age started sex work • * percents are RDS weighted

  13. Behaviour - # clients last week • * percents are RDS weighted

  14. Overall HIV prevalence 56.4% (95% CI 42.2-80.0) • * percents are RDS weighted

  15. Consistent condom usewith clients • Other attributes 59.3 % (36.4 - 83.3) • Ever experienced IPV 37.4% (17.3 - 59.1) • Ever experienced Client BV 28.3% (10.8- 58.0) • Raped in last 12 months 4.3% (1.1-13.2) • * percents are RDS weighted

  16. HIV Care Cascade

  17. 100% • maybe consider 95% CI’s since have • given them throughout • Additional 19% with viral suppression but reporting not on ART • 61% • 50% • 40% • 31%

  18. In summary • Programmatic and past research data suggest SWs are not adequately linked to services • Analysis of baseline survey data suggests that service access is improving but still sub-optimal, particularly in terms of testing and diagnosis. • Trial will provide evidence of cost effectiveness of strengthening ART provision for both prevention and treatment among SWs

  19. Acknowledgements And Others Valentina Cambiano UCL Samson Chidiya – UNFPA Tarisai Chinyaka – CeSHHAR Calum Davey – LSHTM Jeffrey Dirawo – CeSHHAR Vimbai Mdege NAC Sibongile Mtetwa - CeSHHAR Sithembile Msembiri - CeSHHAR Phillis Mushati - CeSHHAR BasileTambashe - Country Representative UNFPA Co Investigators • Joanna Busza - LSHTM • Valentina Cambiano - UCL • Dr Milton Chemhuru Provincial Medical Director Midlands • Dagmar Hanisch -UNFPA • James Hargreaves LSHTM • Dr Nyasha MasukaPMD MatebelelandNorth • Sue Mavedzenge RTI International • Dr Owen Mugurungi – Director HIV AIDS and TB Unit, MoHCC • Andrew Phillips UCL • Professor Simba Rusakaniko UZ-CHS

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