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Understanding Cohort Studies: Design, Examples, and Analysis | Dive into Epidemiology Research Methodology

Learn the fundamentals of cohort studies, including design variations, examples like the JHU Precursors Study and Framingham Study, and analysis methods. Uncover how cohort studies help identify relationships and trends in defined populations.

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Understanding Cohort Studies: Design, Examples, and Analysis | Dive into Epidemiology Research Methodology

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  1. Cohort Study Overview Jeanne M. Clark, MD, MPH Division of General Internal Medicine

  2. Defined Population Exposed Not Exposed Non-random selection Develops Disease No Disease Develops Disease No Disease Design of Cohort Studies Examples: JHU Precursors Study Framingham Study Identify: Can start here: (less common)

  3. 2000 Defined Population Exposed Not Exposed Non-random selection Develops Disease No Disease Develops Disease No Disease 2001 2008 Prospective (Concurrent) Cohort Typically active, scheduled follow-up of some kind

  4. 1988 Defined Population Exposed Not Exposed Non-random selection Develops Disease No Disease Develops Disease No Disease 1998 2008 Retrospective (Non-Concurrent) Cohort Generally passive or post-hoc follow-up of some kind

  5. Analysis of Cohort Studies

  6. Comparison of 4 Major Study Designs Goal or Feature RCT CS CC X-S • Estimate Prevalence F F F A+ • Estimate Incidence B- A+ F F • Prove Causality A+ B+ B- D • Generalizability B- A- A- A • Feasibility C B A A RCT=Randomized, controlled trial; CS=Cohort study; CC=Case-control study; X-S=Cross-sectional study

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