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DCM demo

This study explores the neural dynamics underlying Mismatch Negativity (MMN) using the Dynamic Causal Modeling (DCM) approach. It investigates how the backward connections and inter-area connectivity contribute to generating the MMN response in the auditory cortex.

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DCM demo

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  1. DCM demo André Bastos and Martin Dietz Wellcome Trust Centre for Neuroimaging

  2. Mismatch negativity (MMN) paradigm and hypothesis Paradigm: standards deviants time pseudo-random auditory sequence 80% standard tones – 500 Hz 20% deviant tones – 550 Hz Hypothesis: MMN is caused by recurrent dynamics enabled by backward connections + Deviant ERP Standard ERP amplitude (μV) 0 - 0 200 time (ms) Garrido et al., Neuroimage 2007

  3. Mismatch Negativity scalp topography of ERPs Hypothesis: + MMN is caused by recurrent dynamics enabled by backward connections Deviant ERP Standard ERP amplitude (μV) 0 time (ms) - 0 200 standard time (ms) sensors deviant sensors 0 100 200

  4. The generative model Source dynamics f Observation model g states x Evoked response parameters θ data y Input u David et al., Neuroimage 2006; Kiebel et al., Neuroimage 2006

  5. Forward - F Both - FB Backward - B DCM specification What set of areas and interconnections caused the MMN? 5 several plausible models… IFG + amplitude (μV) 0 4 3 STG rIFG STG - rSTG lSTG 0 200 time (ms) 2 1 A1 A1 Deviant response Standard response Opitz et al., 2002 input modulation of effective connectivity Garrido et al., Neuroimage 2007

  6. IFG IFG IFG Forward and Forward - F Backward - B Backward - FB STG STG STG STG STG STG STG A1 A1 A1 A1 A1 A1 input input input Forward Forward Forward Backward Backward Backward Lateral Lateral Lateral DCM specification of different models modulation of effective connectivity Garrido et al., Neuroimage 2007

  7. Analysis steps 0. Have a HYPOTHESIS! Preprocessing and SVD decomposition Model specification: specify cortical areas and inter-areal connections for various competing models that you think might explain your data Model inversion: find the parameters that minimize differences between observed measurements and model predictions for each of the competing models Bayesian model comparison: make a statistical inferences about which model best describes the data

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