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Genetics of Asthma International Network (GAIN)

Genetics of Asthma International Network Sreekumar Pillai GlaxoSmithKline, Research and Development. Genetics of Asthma International Network (GAIN). A multi-center nuclear family collection designed to study the genetics of asthma 11 Centers in Europe, Australia, US and Barbados

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Genetics of Asthma International Network (GAIN)

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  1. Genetics of Asthma International NetworkSreekumar PillaiGlaxoSmithKline, Research and Development

  2. Genetics of Asthma International Network (GAIN) • A multi-center nuclear family collection designed to study the genetics of asthma • 11 Centers in Europe, Australia, US and Barbados • Ascertained through an affected proband with physician’s diagnosis of asthma with at least one more sibling with asthma • 1018 families ascertained: DNA and phenotypic data available for ~4500 subjects

  3. Progenitor Asthma Study • Samples collected by Mercator Genetics/ Progenitor • 3 Centers • Denmark: Jorgen Vestbo • Minnesota: Malcolm Blumenthal • Israel: Dror Harats

  4. Asthma Family Collections

  5. Demographic Characteristics (GAIN)

  6. Demographic Characteristics (Progenitor)

  7. Strengths • Family based study • All data points collected in children and parents • Multi-center collection • Large sample size • Same protocol used in all centers • Environmental exposure data • Lung function & Methacholine challenge tests • Atopy information (SPT and IgE) • Smoking history • Passive smoking history

  8. Ongoing Collaborations • GABRIEL • Children from GAIN study included in GWAS • Channing (Scott Weiss) • Parents from UK families for GWAS

  9. GAIN Investigators Progenitor Investigators Acknowledgements

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