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Personalised medicine in Sweden

This comprehensive overview explores the resources, implementation strategies, and collaborative efforts driving the advancement of personalised medicine (PM) in Sweden. It delves into the involvement of patients, politicians, clinicians, and various stakeholders across academia, industry, and healthcare to support the integration of PM into practice. Case studies and examples showcase the potential of PM in improving patient outcomes and the need for proof-of-concept studies to demonstrate its clinical feasibility within specific diseases. The narrative emphasizes the importance of national coordination and dedicated funding for furthering PM initiatives in Sweden.

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Personalised medicine in Sweden

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  1. Personalised medicine in Sweden Mikael Benson, Centre for Personalised Medicine, Linköping University

  2. Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  3. Resources for Personalised Medicine (PM) in Sweden • Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  4. Example from Multiple Sclerosis: Combinations of genetic, clinical and environmmental factors for PM Olsson T el al. Nature Rev Neurol (In press)

  5. Drugs and life style changes for PM

  6. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  7. Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years Analyses of health economics

  8. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  9. Example from Linköping University/University Hospital

  10. Centre for PersonalisedMedicine (CPMed), Linköping

  11. Centre for PersonalisedMedicine (CPMed), Linköping

  12. Ryhov County Hospital “Unselected” patients County Hospital conditions important for implementation • Futurum Academy for clinical research

  13. Centre for PersonalisedMedicine (CPMed), Linköping • University Hospital • Medical faculty • Technicalfaculty • CPMed • Multi-disciplinary team: omics, bioinformatics, functional and clinical researchers • National and international collaborations • Industry

  14. Regional investigationabout PM in East Gothia (Östergötland) • Are there diseases that are particularly suitable for implementation of PM within 3-5 years? • A health economics analysis for a regional effort towards PM

  15. Resources for Personalised Medicine (PM) in Sweden • Patient • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  16. Industry Example from AstraZeneca

  17. AstraZeneca 80 % of drug pipeline includes PM components Combining omics analyses of 2 million patients with clinical data to find subgroups and new targets Several collaborations with academia

  18. Industry Diagnostics: biotech, biomarkers and software Health care industry

  19. Big US companies are investing heavily in personalised medicine

  20. Patients • Politicians • Clinicians • Ethics • Health Care • PM • Funders • Academia • National Resources • Industry • International Collaboration

  21. National resources Population-wide registries Bioinformatics (BILS) • Biobanks (BBMRI) SciLife Lab National high performance computer

  22. Funders Swedish Research Council Vinnova Swedish Foundation for Strategic Research Wallenberg Foundation

  23. Example VR and Vinnovaarelaunching a National programme in protein research and biopharmaceuticaldrugs (320 millions SEK for 2016-2023)

  24. Need for proofofconcept studies Projects that show clinical feasibility of PM in specific diseases within 3-5 years

  25. Summary • PM already partially implemented in health care • All resources for general implementation are available in Sweden • Need for national coordination and dedicated funding for clinically oriented proof-of concept studies

  26. Multi-Layered Disease Modules for Personalised medicine

  27. Population-wide

  28. Ideal • Equality in health care

  29. Problem • Equality in health care ≠same care ?

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