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Polymerase δ and ε in colon cancer

Polymerase δ and ε in colon cancer. Aaron Stevens. Polymerase δ and ε contain both polymerase and exonuclease domains . Polymerase δ and ε are the major replicative polymerases. Pol δ and ε help repair damage. Mutating the exonuclease domain leads to decreased survival rates.

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Polymerase δ and ε in colon cancer

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  1. Polymerase δ and εin colon cancer Aaron Stevens

  2. Polymerase δ and ε contain both polymerase and exonuclease domains

  3. Polymerase δ and εare the major replicative polymerases

  4. Pol δ and εhelp repair damage

  5. Mutating the exonuclease domain leads to decreased survival rates

  6. Point mutations in Pol δare found in colon cancer

  7. Mutating the exonucleasedomain of Polymerase δleads to cancer

  8. References • Biard Denis S.F. (2011). New Insight on Entangled DNA Repair Pathways: Stable Silenced Human Cells for Unraveling the DDR Jigsaw, DNA Repair - On the Pathways to Fixing DNA Damage and Errors, Dr. Francesca Storici (Ed.), ISBN: 978-953-307-649-2, InTech, DOI: 10.5772/23681. • Prindle, M. J. and Loeb, L. A. (2012), DNA polymerase delta in dna replication and genome maintenance. Environ. Mol. Mutagen., 53: 666–682. doi: 10.1002/em.21745 • Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ, Preston BD. High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading. PNAS.2002;99(24):15560–15565. doi: 10.1073/pnas.232340999. • Burgers P. M. (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J. Biol. Chem. 284, 4041–4045 • Albertson T. M., Ogawa M., Bugni J. M., Hays L. E., Chen Y., Wang Y.,Treuting P. M., Heddle J. A., Goldsby R. E., Preston B. D. (2009) DNA polymerase ϵ and δ proofreading suppress discrete mutator and cancer phenotypes in mice.Proc. Natl. Acad. Sci. U.S.A. 106, 17101–17104 • Helmut Pospiech and Juhani E. Syväoja, “DNA Polymerase ε - More Than a Polymerase,”TheScientificWorldJOURNAL, vol. 3, pp. 87-104, 2003. doi:10.1100/tsw.2003.08 • Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337 • Q. Zhou, R. Effati, K. Talvinen, H. Pospiech, J.E. Syväoja, Y. Collan. Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer. Cancer Genomics Proteomics, 5 (2008), pp. 287–292

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