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A Musical Metaphor for Matrix Function

S S. A Musical Metaphor for Matrix Function. Cytoplasm. Plasma membrane. Plasma membrane. More complex signals organized both in space in the cell (e.g., focal complexes, contacts and adhesions) and in relation to the surroundings (biological context).

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A Musical Metaphor for Matrix Function

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  1. S S A Musical Metaphor for Matrix Function Cytoplasm Plasma membrane Plasma membrane More complex signals organized both in space in the cell (e.g., focal complexes, contacts and adhesions) and in relation to the surroundings (biological context).

  2. Integrin-Growth Factor Receptor Crosstalk • Lössner D, et al., Integrin v3mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells, Int J Biochem Cell Biol (2008), doi:10.1016/j.biocel.2008.05.014 • Lee, et al., Integrin Regulation by Vascular Endothelial Growth Factor in Human Brain Microvascular Endothelial Cells, The Journal of Biological Chemistry Vol. 281, no. 52, pp. 40450–40460, December 29, 2006

  3. EGFR upregulation leads to increased proliferation

  4. Northern

  5. Integrin-Growth Factor Receptor Crosstalk Shu-Yi Chen and Hong-Chen Chen, Direct Interaction of Focal Adhesion Kinase (FAK) with Met Is Required for FAK To Promote Hepatocyte Growth Factor-Induced Cell Invasion, Molecular and Cellular Biology, July 2006, p. 5155–5167

  6. Integrin-Growth Factor Receptor Crosstalk Short et.al., Integrin-mediated Signaling Events in Human Endothelial Cells, Molecular Biology of the Cell Vol. 9, 1969–1980, August 1998

  7. Integrin-Growth Factor Receptor Crosstalk • Moro et. al., Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival, The EMBO Journal Vol.17 No.22 pp.6622–6632, 1998 • Borges et al., Platelet-derived Growth Factor Receptor  and Vascular Endothelial Growth Factor Receptor 2 Bind to the 3 Integrin through Its Extracellular Domain The Journal of Biological Chemistry Vol. 275, No. 51, Issue of December 22, pp. 39867–39873, 2000 • Mahabeleshwar et.al., Mechanisms of Integrin Vascular Endothelial Growth Factor Receptor Cross-Activation in Angiogenesis Circ. Res. 2007;101;570-580 • Zhang et. al., Extracellular Matrix Regulates Endothelial Functions Through Interaction of VEGFR-3 and Integrin 51 Journal of Cellular Physiology 202:205–214 (2005)

  8. Interaction independent of ligand Cytoplasmic tail not needed Extracellular domain mediates interaction

  9. Src phosphorylates 3 Src phosphorylation determines 3 activity

  10. 3 cytoplasmic tyrosine motifs are required for v3-dependent migration of ECs and EC tube formation

  11. Blocking antibodies Effects on PI3K acivity

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