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Key transcription factor regulatory circuit controlling cytokine production and inflammation

Key transcription factor regulatory circuit controlling cytokine production and inflammation. TLR4. Attenuator. Initiator. NF- kB. P. Miz1. Atf3. Terminator. Cebpd. Il6. Amplifier. Litvak et. al Nature Immunology (2009). Do- Umehara and Cong et. al Nature Immunology (2013).

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Key transcription factor regulatory circuit controlling cytokine production and inflammation

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  1. Key transcription factor regulatory circuit controlling cytokine production and inflammation TLR4 Attenuator Initiator NF-kB P Miz1 Atf3 Terminator Cebpd Il6 Amplifier Litvak et. al Nature Immunology (2009) Do-Umeharaand Cong et. al Nature Immunology (2013)

  2. Our Complex System B C A 10 minutes 10 minutes 30 minutes 10 minutes

  3. Drug Design Techniques • Add a protein • Degrade a protein (make the protein useless) • Add a catalyst that increases a reaction rate • Add a molecule that blocks certain binding partners

  4. Patients need high protein C levels at least 30 minutes after infection to survive the flu. Design a drug that will give 100% survival. Use at least two of the drug design techniques discussed Draw a new model including your drug. Come up with ideas of how this drug would be working, i.e. if it’s blocking the binding, show shapes for how that might happen and Be able to explain why this changes the rates of reactions Give the total number of protein molecules in your system after 30 minutes

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