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The Myc Transcription Factor

The Myc Transcription Factor. By: Michael Reisfeld. MYC Was Originally cloned From a transforming Virus. Myc is a Transcription Factor Which Dimerizes With a Leucine Zipper and binds to DNA Via a Helix-Loop-Helix. Myc is part of pathway that promotes Cell Proliferation.

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The Myc Transcription Factor

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  1. The Myc Transcription Factor By: Michael Reisfeld

  2. MYC Was Originally cloned From a transforming Virus

  3. Myc is a Transcription Factor Which Dimerizes With a Leucine Zipper and binds to DNA Via a Helix-Loop-Helix

  4. Myc is part of pathway that promotes Cell Proliferation

  5. Myc Targets a Huge Array of Genes to Perform This Function

  6. Myc is a Family of Three Proteins, in Which Each Possesses a Slightly different Function

  7. Overexpression of Each Specific Myc Protein Is Responsible for Corresponding Tumor Types Neuroblastoma (N-myc) Burkitt’s Lymphoma (c-myc) Small Cell Lung Cancer (L-myc)

  8. c-Myc Overexpression Can Induce Tumors

  9. A More Human Side…

  10. Burkitt’s Lymphoma • 2% of Lymphoproliferative Disorders • C-myc translocation associated with ALL cases • 85% involve translocation to IGH

  11. Is Myc a Viable Target for Treatment?

  12. Works Cited Bellan, C et al. “Burkitt’s lymphoma: new insights into molecular pathogenesis.” Journal of Clinical Pathology. 11 July 2002; 56:3, 188-192. CollerHA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, et al. ”Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.” ProcNatlAcadSciUSA. 2000; 97(7):3260-5. Dalla-Favera R, et al. “Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosisvirus (MC29).” ProcNatlAcadSciU S A. 1982;79:6497–501 Ellwood-Yen, Katherine et al. “Myc-driven murine prostate cancer shares molecular features with human prostate tumors.” UClA. Hatton, Kimi S et al. “Expression and Activity of L-Myc in Normal Mouse Development.” Molecular and Cellular Biology. 1996; 16:4, 1794-1804 Henriksson, Marie and Marina Vita. “The Myc oncoprotein as a therapeutic target for human cancer.” Seminars in Cancer Biology.2006; 16, 318-330 Laurenti, Elisa et al. “Hematopoietic Stem Cell function and Survival Depend on c-myc and N-myc activity.” Cell Stem Cell. 4 Dec 2008; 3:6, 611-624 Nesbitt, Chad et al. “Myc Oncogenes and human neoplastic disease.” Oncogene. 13 May 1999; 18:19, 3004-3016 Penn, Linda Z and Amanda R. Wasylishen. “Myc: The Beauty and the Beast.” Genes and Cancer. 26 July 2010; 1:6, 532-541 Wey, Alice et al. “c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development.” Cerebellum. Dec 2010; 9:4, 537-547 http://www.thepoultrysite.com/publications/6/diseases-of-poultry/203/myelocytomatosis .http://www.scripps.org/articles/1391-neuroblastoma http://www.aboutcancer.com/LUNG_CANCER_PET_8_06._2.pg.jpg

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