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Urinary system: Histology of renal tubule, juxtaglomerular apparatus, ureter, and bladder

Urinary system: Histology of renal tubule, juxtaglomerular apparatus, ureter, and bladder. Lecture 35 Friday, March 23, 2007 Refs. Ross Chapter 20, Wheater’s Chapter 16 Basic Pathology Chapter 14. Nephrons: Cortical nephron and Juxtamedullary nephron Ross 20.3.

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Urinary system: Histology of renal tubule, juxtaglomerular apparatus, ureter, and bladder

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  1. Urinary system: Histology of renal tubule, juxtaglomerular apparatus, ureter, and bladder Lecture 35 Friday, March 23, 2007 Refs. Ross Chapter 20, Wheater’s Chapter 16 Basic Pathology Chapter 14

  2. Nephrons:Cortical nephron and Juxtamedullary nephron Ross 20.3

  3. Medullary rays are groups of straight tubules and collecting ducts extending into cortex. Ross 20.6a and b

  4. Proximal convoluted tubuleazan stain WFH 16.15a

  5. Proximal convoluted tubule.PAS stain shows brush border (microvilli) and basement membrane. WFH 16.15b

  6. Proximal convoluted tubuleTEM 600 x WFH 16.15c

  7. Basolateral membrane of proximal convoluted tubule cells showing lateral interdigitations and mitochondriaTEM 8500 x WFH 16.15d

  8. Medulla with transverse sections of tubules WFH. 16.16aKey: CD, collecting duct; CT, collecting tubule; A, thick ascending limb; T, thin limb; V, vasa recta

  9. Longitudinal section of medulla WFH 16.16b

  10. Convoluted tubules: Proximal (PCT) and Distal (DCT) WFH 16.17a

  11. Distal convoluted tubules among PCTPAS stain WFH 16.17b

  12. PCT Tall cuboidal lining Smaller lumen Brush border More organelles (more eosinophilic cytoplasm) Appear more numerous (longer segment) DCT Low cuboidal lining Larger lumen few microvilli Less eosinophilic cytoplasm Appear less numerous (shorter segment) Histologic differences between PCT and DCT

  13. Distal convoluted tubuleTEM 3000 x WFH 16.17c

  14. Juxtaglomerular apparatus Azan stain WFH 16.18a

  15. Schematic juxtaglomerular apparatus WFH 16.18b

  16. Juxtaglomerular ApparatusRoss 20.7

  17. Structure Distal convoluted tubule Mesangium Afferent arteriole Note that the afferent arteriole and DCT are parts of the same nephron. Specific part of structure Macula densa Lacis cells or extra-glomerular mesangial cells Juxtaglomerular cells or granular cells Components of the juxtaglomerular apparatus

  18. Control of blood pressure WFH 16.18c

  19. Collecting ducts WFH 16.19b

  20. Outer Medulla Key:CT, collecting tubule; H, thin loops of Henle; V, vasa recta; S, supporting tissue; F, fibroblast; L, leukocyte.TEM 4000 x WFH 16.20

  21. Renal papilla WFH 16.23Key: DB, ducts of Bellini; SM, smooth muscle; E, transitional epithelium; U, ureter.

  22. Transverse section of ureter WFH 16.23Note that the inner muscle is longitudinal and outer is circular.

  23. Wall of urinary bladder WFH 16.24Key: IL, inner longitudinal; OC, outer circular, OL, outermost longitudinal layers of smooth muscle; A, adventitia.

  24. Transitional epithelium or urotheliumWFH 16.25The stratified epithelium that lines calices, pelvis, ureter, bladder, and proximal urethra.Key: U, umbrella cells; LP, lamina propria; C, capillary.

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