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Prenatal and Early Life Factors in Breast Cancer: Slovak Study

Exploring prenatal and childhood factors in relation to adult breast cancer development. Study conducted in Slovakia focusing on early life risk factors and interventions for prevention. Data from birth registries and medical records utilized for analysis. Prospective case-control study in Trnava region with potential implications for breast cancer prevention strategies among adolescents. Acknowledgment to Fogarty Center of NIH for funding support.

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Prenatal and Early Life Factors in Breast Cancer: Slovak Study

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  1. Prenatal and childhood origin of an adult disease; The case of breast cancer Gabriel Gulis SDU Esbjerg, Denmark Anna Pakosova Trnava University, Trnava, Slovakia

  2. Breast cancer mortality

  3. Breast cancer morbidity

  4. Major risk factors • Hormonal risks (menarche, parity, menopause) • Lifestyle (diet, alcohol, smoking, physical exercise) • Medications (oral contraceptives, HRT) • Genetic predisposition • Early life risk factors

  5. Early life risk factors • birthweight • birth length • gestational age at birth • twin, zygosity • age of mother at delivery • weight and height of mother in/out of pregnancy • birth order

  6. What data are available in Slovakia • Presentation of data and data soruces available in Slovakia on early life risk factors Data sources:birthbook birthregistry medical record

  7. Data from Birthbook • Birthweight/birthlength • twin, zygosity • gestational age at birth • age of mother at delivery • birth order

  8. Data of birth registry • Birthweight/birth length • twin, zygosity • gestational age at birth • age of mother at delivery • birth order *data from birth registry are available since 1959

  9. Data from Medical record • Birthweight/birth length • twin, zygosity • age of mother at delivery • birth order • weight/height of mother at different ages • age at menarche • age at menopause

  10. Data from Medical record • Use of oral contraceptives • use of hormone contraceptives • alcohol • smoking

  11. Changes of data sources over time

  12. Description of Slovak study - methodology • Prospective, hospital based case-control study • Trnava region, Trnava and Skalica district hospitals • 3 years, 250 cases and controls • Newly diagnosed histologically confirmed cases, if possible at the beginning of treatment • Age and region matched controls by frequency matching

  13. Description of Slovak study – practical performance • Key collaborators in hospitals are head nurses, good collaboration with heads of oncology departments as well

  14. Possibilities forintervention • Based on study we expect to bring new field for breast cancer prevention among adolescents: • Increaseinformation campaigns in schools • Breast cancer awareness programs, risk factors, determinants • Involvment of pediatricians

  15. Summary • Work in progress, first experiences • Interest of clinicians from hospitals is crucial • High willingness of cases to participate • Implications for intervention

  16. Acknowledgement: The authors acknowledge a grant number R03 TW 06137 of Fogarty Center of NIH, USA which made the study possible

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