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Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

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Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors

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    1. Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors By: Jared Rutter, Martin Reick, Leeju C. Wu, Steven L. McKnight

    2. Review We will be focusing on the Bmal-1 Clock heterodimer NPAS2 is a functional analog of CLOCK but is only expressed in certain tissues NPAS2:BMAL1 heterodimer inhibits BMAL1 ensures oscillation We will be focusing on the Bmal-1 Clock heterodimer NPAS2 is a functional analog of CLOCK but is only expressed in certain tissues NPAS2:BMAL1 heterodimer inhibits BMAL1 ensures oscillation

    3. NPAS2 NPAS2 is a functional analog of CLOCK Only expressed in certain tissues such as the prefrontal cortex NPAS2:BMAL1 heterodimer represses BMAL1 expression

    4. Objective To identify the mechanism by which circadian rhythms can be entrained to food ingestion

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