1 / 13

MICROBIAL MECHANISMS OF PATHOGENICITY.

MICROBIAL MECHANISMS OF PATHOGENICITY. Entry of a microorganism into a host. PORTALS OF ENTRY. Mucous Membranes. Skin. Parenteral Route. Preferred portals of entry. Numbers of Invading Microbes. Adherece. HOW MICROBES PENETRATE HOST DEFENSE. Capsules. Components of the cell wall.

burton
Download Presentation

MICROBIAL MECHANISMS OF PATHOGENICITY.

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MICROBIAL MECHANISMS OF PATHOGENICITY. Entry of a microorganism into a host.

  2. PORTALS OF ENTRY. • Mucous Membranes. • Skin. • Parenteral Route. • Preferred portals of entry.

  3. Numbers of Invading Microbes. • Adherece.

  4. HOW MICROBES PENETRATE HOST DEFENSE. • Capsules. • Components of the cell wall. • Enzymes. • .

  5. ENZYMES. • Leukocidins. • Hemolysins. • Coagulases. • Bacterial Kinases. • Hyaluronidase. • Collagenase. • Others:hypothermic factors, lecithiase, siderophores.

  6. HOW MICROBES DAMAGE HOST CELLS. • Direct Damage. • Production of Toxins.

  7. PRODUCTION OF TOXINS. • Exotoxins: Three Principal types. • Cytotoxins • Neurotoxins • Enterotoxins

  8. NOTABLE EXOTOXINS. • Diphtheria toxin. • Erythrogenic toxins. • Botulinum toxin. • Tetanus toxin. • Vibrio enterotoxin. • Staphylococcal enterotoxin.

  9. ENDOTOXINS. • Exotoxin VS Endotoxin. • Endotoxins and the Pyrogenic response.

  10. PLASMIDS, LYSOGENY, AND PATHOGENICITY. • Resistance Factors. • Virulence Factors. • Lysogeny/Prophage.

  11. Pathogenic Properties of Non-bacterial Microorganisms. • Mimicing substances useful to the host cell. • Viruses hiding their attachment sites from host’s immune system.

  12. CYTOPATHIC EFFECTS OF VIRUSES. • CPE. • Inclusion bodies. • Syncytia or Giant cells. • Interferon.

  13. FUNGI, PROTOZOA, HELMINTHS, and ALGAE. • Fungi: Sclerotia, ergot, aflatoxin, mycotoxins. • Protozoa. • Helminths. • Algae.

More Related