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Guy Kleinmann, MD 1 Shmuel Ben-Elihau, DVM 2

Biocompatibility of a New Hydrophobic Acrylic Material for Fabrication of IOLs. Guy Kleinmann, MD 1 Shmuel Ben-Elihau, DVM 2. Ophthalmology Department, Kaplan Medical Center Harlan Biotech Israel. Guy Kleinmann is a consultant for Hanita Lenses. Purpose.

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Guy Kleinmann, MD 1 Shmuel Ben-Elihau, DVM 2

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  1. Biocompatibility of a New Hydrophobic Acrylic Material for Fabrication of IOLs Guy Kleinmann, MD1 Shmuel Ben-Elihau, DVM2 • Ophthalmology Department, Kaplan Medical Center • Harlan Biotech Israel Guy Kleinmann is a consultant for Hanita Lenses

  2. Purpose To evaluate the biocompatibility of a new hydrophobic IOL material; the Benz-HF1 Natural Yellow, Using the SeeLens IOL (Hanita, Israel) as a platform

  3. Methods • 10 NZW rabbits • Each rabbit was randomly implanted with the new hydrophobic IOL in one eye and B-lens IOL (Hanita, Israel)in the fellow eye • Follow up: 1D, 1W, 1M, 3M, 6M • Each follow up included: • Photography • Slit lamp clinical evaluation

  4. Methods – cont. • At the end of the study: • Enucliation of the eye • Explantion of the lens • Histological evaluation of the eye • SEM/EDS of the explanted IOLs • Analysis of the explanted IOLs: • Light microscopy analysis (all IOLs) • Transmission spectrum (half of the IOLs) • Scanning electron microscopic + energy dispersive x-ray (SEM/EDX) (half of the IOLs) • Two non-implanted IOLs of each IOL served as negative controls

  5. Results: Macroscopic 1 month New Hydrophobic Control

  6. ResultsSlit lamp evaluation 1 month 3 months 6 months Control New Hydrophobic

  7. Results 6 months slit lamp evaluation

  8. Histopathological results

  9. Histology summary • No treatment related nor material related changes were noted • All reported changes had comparable incidence in both groups

  10. SEM/EDS of explanted IOLs Control New Hydrophobic

  11. Explanted IOLs- summary The Investigated hydrophobic study IOLs were superior in comparison to the control lenses

  12. Discussion • The Benz-HF1 Natural Yellow material was found to be superior to the hydrophilic IOL in all the IOL analysis parameter • No difference between the groups was found in the clinical and histological evaluations Conclusion The Benz-HF1 Natural Yellow material, using the SeeLens IOL platform (Hanita, Isreal), demonstrated excellent biocompatibility in the Rabbit model of ocular implantation test

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