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Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong

MYOPIC CHOROIDAL NEOVASCULARISATION. *A review of the natural history and prognostic factors. Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong. National Healthcare Group Eye Institute, Singapore. * The authors have no financial or proprietary interest in the subject of this topic.

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Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong

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  1. MYOPIC CHOROIDAL NEOVASCULARISATION *A review of the natural history and prognostic factors Colin Tan, Alex Tham, Tiakumzuk Sangtam, Kah-Guan Au Eong National Healthcare Group Eye Institute, Singapore * The authors have no financial or proprietary interest in the subject of this topic

  2. OBJECTIVE & METHODS Objective: • To review the: • Epidemiology • Natural history • Prognostic factors of myopic choroidal neovascularisation (CNV), a potentially blinding condition. Methods: • Systematic PubMed search was performed to review English-language publications on myopic CNV

  3. RESULTS • High myopia was the aetiological factor in 62% of cases • One study of 354 eyes with myopic CNV demonstrated that 96% of choroidal neovascular membranes remained stable or regressed with scarring. • However, the visual prognosis of untreated myopic CNV is poor, with final visual acuities (VA) of 20/100 or less in several studies.

  4. RESULTS • Review of 100 untreated eyes • After 5 years • 100% of lesions involved the foveal center • Mean visual acuity of 20/160. • Visual acuity significantly lower than similar group treated with laser photocoagulation • 10-year follow-up of 27 Asian eyes • VA dropped to 20/200 or worse • After 5 years: 88.9% • After 10 years: 96.3% • Prognostic factors for visual outcome of myopic CNV • Age at onset of CNV • Location and size of CNV • Initial best-corrected visual acuity.

  5. RESULTS

  6. CONCLUSION • Pathologic myopia is the cause of CNV in a large proportion of patients • Younger than 50 years of age • Long-term visual prognosis of untreated CNV is poor • Visual acuities of 20/100 or less • After 5 to 10 years in a large proportion of patients

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