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Fischer Esterification

Fischer Esterification. Maria Victoria Silva Elipe. Fischer Esterification Reaction Detailed Methodology. 1.8mL MeOH + 0.2mL CD3OD. The CD3OD is to lock in methanol so easy for the shimming and aligning of the signals over time. 2mL AcOH + 10uL H2SO4.

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Fischer Esterification

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  1. Fischer Esterification Maria Victoria Silva Elipe

  2. Fischer Esterification ReactionDetailed Methodology • 1.8mL MeOH + 0.2mL CD3OD. The CD3OD is to lock in methanol so easy for the shimming and aligning of the signals over time. • 2mL AcOH + 10uL H2SO4. • I took 300 uL of the MeOH+CD3OD and added with a syringe in the outer chamber which is wider and help shimming because there is more volume there and that’s why I need some CD3OD. • I took 300 uL of the AcOH+H2SO4 and added in the inner chamber with a syringe with long needle to make sure the liquid reach the bottom of the tube (if the liquid is viscose it is not easy to put all the liquid down but a syringe with very long needle helps because my long needles reach the bottom of the tube-I avoid to shake the tube specially before mixing for precaution). • I tune and shim and take spectrum. • I take the tube out and lift the inner tube enough to mix the liquids from both chambers but now I don’t remove the inner tube, just lift it enough for the mixing. • I put the sample inside the magnet and I shim again to make sure no signal degradation and take spectra over time. Sometimes I may do autoshiming to make sure no degradation of shimming occurs during time due to changes on pH and concentration during the reaction. • I use Mnova software to do all the analysis of the reaction including calculating concentrations overtime.

  3. C' = B+F*exp(-t*G)B=6.224; F=3.478; G=0.6907;Error: 0.08679 C1' = B+F*exp(-t*G)B=4.015; F=-3.735; G=0.7729;Error: 0.02697

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