Sarah E. Bondos , The Texas A&M University System HSC Research Foundation, DMR 1151394

1. CAREER: Using Functionalized Protein-based Materials to Control and Pattern Cell Behavior Sarah E. Bondos, The Texas A&M University System HSC Research Foundation, DMR 1151394 Intellectual Merit: An ideal tissue engineering scaffold would not only support three dimensional cell growth, but also incorporate and pattern factors that regulate cell behavior. We have developed a novel method to purify, integrate, and pattern recombinant protein into biomaterials in a single step that preserves protein structure and activity. We are using this technique to identify new factors that stimulate or inhibit the formation of blood vessels. Angiogenesis: Inhibition Control Stimulation Ubx fibers (green) can carry factors that stimulate or inhibit blood vessel formation, thus patterning the placement of the vessels. BSA fiber SIP/BSA fiber S1P adsorbed onto Ubx fibers stimulates and guides cell migration and angiogenesis.

2. CAREER: Using Functionalized Protein-based Materials to Control and Pattern Cell Behavior Sarah E. Bondos, The Texas A&M University System HSC Research Foundation, DMR 1151394 Broader Impacts: Engaging undergraduates in research Our collaboration with an undergraduate biochemistry laboratory course at the University of Houston, enables 60-70 students per year to participate in cutting-edge research while learning molecular biology and protein chemistry techniques. Outstanding students from this class do summer research projects in our lab and continue their research at the University of Houston during the academic year.