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Nice, round particle

Silica-Polypeptide Composite Particles (and Worms) Paul S. Russo, Louisiana State University, DMR 1005707.

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Nice, round particle

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  1. Silica-Polypeptide Composite Particles (and Worms)Paul S. Russo, Louisiana State University, DMR 1005707 We make small (1/1000th of a millimeter) particles, each composed of a solid, glass-like core and magnetic “nougat”, all coated by a soft, protein-like shell. The particles may someday be used to carry anticancer drugs to tumor sites, guided by interaction of the magnetic nougat with an applied magnetic field. A sample particle appears as the top image. This year, progress has been made in preparing these materials by a new, more efficient chemistry, and we have located collaborators familiar with anticancer therapy. But this report focuses on what happens when things go wrong. The lower figure shows a “microworm”, an unwanted byproduct. What is the best approach when things go wrong? Nice, round particle Undesirable microworm

  2. Silica-Polypeptide Composite Particles (and Worms) Paul S. Russo, Louisiana State University, DMR 1005707 Technical Broader Impact.The “bad” microworms in Slide #1 can be isolated from the “good” spheres, but could we do more? Nature provides a clue. The worms resemble magnetotactic bacteria , micro-organisms which know north from south and use their end-attached tails to swim accordingly. We will try to attach polypeptide tails to the worms; although they will not swim, we may succeed at guiding the particles as they move through solution under an applied field. NSF is training young scientists to convert hardship to opportunity. As mom instructed, given lemons, make lemonade. Non-technical Broader Impact.Work with the Chemical Educational Foundation continues. Shown are sample questions the contestants must answer orally and without calculators during CEF’s “You be the Chemist Challenge” (a national quiz bowl competition). We help to write and vet these questions and promote the program in Louisiana. A radio wave has a wavelength of 100 m and the speed of light is 3 x 108 m/sec. What is its frequency (per sec)?  a) 30,000 b) 3 x 1010 c) 3.0 x 106 d) 3.33 x 10-5 • What is the charge on the atoms or ions pictured • below (from left to right)? • +1, 0, -2 b) 0, +1, +2 c) -1, 0, +2 d) +1, 0, -1 Two questions from the Chemical Educational Founda-tion’s “You be the Chemist “ Challenge (Grades 5-8). 2010 National Challengers in Philadelphia, PA , June 18. Louisiana State Champ, Jaylun Brumfield (seated, 2nd from left) will join the laboratory of colleague John Pojman this fall. The 2009 National Champion works afternoons in our lab, supported by NSF, and the 2009 State runner-up will join colleague Donghui Zhang ‘s group this fall.

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